Transglutaminase 2 affinity and enzyme‐substrate intermediate stability as determining factors for T‐cell responses to gluten peptides in celiac disease
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249862
Abstract: The adaptive immune response of celiac disease (CeD) involves presentation of gluten peptides to CD4+ T cells by transglutaminase 2 (TG2) specific B cells. This B‐cell/T‐cell crosstalk is facilitated by involvement of TG2:gluten peptide complexes… read more here.
Keywords: gluten peptides; celiac disease; specific cells; tg2 specific ... See more keywords
Comparison of gluten peptides and potential prebiotic carbohydrates in old and modern Triticum turgidum ssp. genotypes.
Sign Up to like & getrecommendations! Published in 2019 at "Food research international"
DOI: 10.1016/j.foodres.2018.11.007
Abstract: Old wheat genotypes are perceived by consumers as healthier than modern ones. The release of gluten peptides with in vitro digestion and the content of potentially prebiotic carbohydrates (i.e. resistant fraction of starch and cell-wall… read more here.
Keywords: triticum turgidum; gluten peptides; old modern; prebiotic carbohydrates ... See more keywords
Analysis of Gluten in a Wheat-Gluten-Incurred Sorghum Beer Brewed in the Presence of Proline Endopeptidase by LC/MS/MS.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b04371
Abstract: Most gluten-reduced beers are produced using an enzyme called proline endopeptidase (PEP), which proteolyzes the gluten by cleaving at proline residues. However, the gluten content of beers brewed in the presence of PEP cannot be… read more here.
Keywords: beer brewed; proline; brewed presence; gluten peptides ... See more keywords
Comprehensive Detection of Isopeptides between Human Tissue Transglutaminase and Gluten Peptides
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DOI: 10.3390/nu11102263
Abstract: Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of gluten in genetically predisposed individuals. Tissue transglutaminase (TG2) is a key factor in CD pathogenesis, because it catalyzes both… read more here.
Keywords: tg2; tissue transglutaminase; tg2 gluten; gluten peptides ... See more keywords
A Case Study of the Response of Immunogenic Gluten Peptides to Sourdough Proteolysis
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DOI: 10.3390/nu13061906
Abstract: Celiac disease is activated by digestion-resistant gluten peptides that contain immunogenic epitopes. Sourdough fermentation is a potential strategy to reduce the concentration of these peptides within food. However, we currently know little about the effect… read more here.
Keywords: digestion; gluten; immunogenic gluten; peptides sourdough ... See more keywords