The influence of season on glutamate and GABA levels in the healthy human brain investigated by magnetic resonance spectroscopy imaging
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26236
Abstract: Seasonal changes in neurotransmitter systems have been demonstrated in imaging studies and are especially noticeable in diseased states such as seasonal affective disorder (SAD). These modulatory neurotransmitters, such as serotonin, are influencing glutamatergic and GABAergic… read more here.
Keywords: magnetic resonance; glutamate; spectroscopy; brain ... See more keywords
Glutamate in dorsolateral prefrontal cortex and auditory verbal hallucinations in patients with schizophrenia: A 1H MRS study
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.05.020
Abstract: Purpose: Glutamatergic models of psychosis propose that dysfunction of N‐methyl‐d‐aspartate (NMDA) receptors, and associated excess of glutamate, may underlie psychotic experiences in people with schizophrenia. However, little is known about the specific relation between glutamate… read more here.
Keywords: lifetime avh; patients schizophrenia; auditory verbal; verbal hallucinations ... See more keywords
P14.92 Study of Glutaminergic and Glutamatergic Metabolism in 1H-MRS Monovoxel in the Most Aggressive Part of 62 Glioblastoma Before and After 18 months Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.327
Abstract: To study the relationships between glutaminergic metabolism (Glx/tCr), tumor proliferation (tCho/tCr) and other metabolic activities in patients with glioblastoma (GBM). Patients: 62 patients with glioblastoma, all having a STUPP Protocol (radiotherapy and concomitant chemotherapy), were… read more here.
Keywords: glx tcr; study; months treatment; glx ... See more keywords
O2.2. EVALUATION OF THE RELATIONSHIP BETWEEN GLUTAMATE AND BRAIN CONNECTIVITY IN ANTIPSYCHOTIC-NAïVE FIRST EPISODE PATIENTS – A COMBINED MAGNETIC RESONANCE SPECTROSCOPY AND RESTING STATE FUNCTIONAL CONNECTIVITY MRI STUDY
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa028.007
Abstract: Abstract Background Schizophrenia is thought to be a disorder of brain dysconnectivity. An imbalance between cortical excitation/inhibition is also implicated, but the link between these abnormalities remains unclear. The present study used resting state functional… read more here.
Keywords: connectivity; group; spectroscopy; glx ... See more keywords
164. Association Between Glutamate + Glutamine in the Left Temporoparietal Junction and Mismatch Negativity (MMN) in Antipsychotic-Naive/Free Schizophrenia Patients With Auditory Hallucinations.
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbx021.222
Abstract: Abstract Background: Mismatch negativity (MMN), a biomarker for schizophrenia, is understood to be dependent on glutamatergic neurotransmission. Although both glutamate and MMN are considered to be of high relevance to schizophrenia pathophysiology, only one study… read more here.
Keywords: naive free; schizophrenia; auditory hallucinations; antipsychotic naive ... See more keywords
Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors
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DOI: 10.2147/dddt.s356621
Abstract: Background Glyoxalase system is one of the defense cellular mechanisms that protect cells against endogenous harmful metabolites, mainly methylglyoxal (MG), through conversion of cytotoxic methylglyoxal into the non-toxic lactic acid. Glyoxalase system comprises of two… read more here.
Keywords: potent glx; glx; inhibitory activity; benzenesulfonamide derivatives ... See more keywords
MR-Spectroscopy of GABA and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.859322
Abstract: Psychosis involves changes in GABAergic and glutamatergic neurotransmission in auditory cortex that could be important for understanding sensory deficits and symptoms of psychosis. However, it is currently unclear whether such deficits are present in participants… read more here.
Keywords: glx; spectroscopy; chr; auditory cortex ... See more keywords
The Relationship Between Resting Cerebral Blood Flow, Neurometabolites, Cardio-Respiratory Fitness and Aging-Related Cognitive Decline
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.923076
Abstract: Older adults typically experience a decline in cognitive function, but improvements in physical health and lifestyle can be neuroprotective across the human lifespan. The primary objective of this study is to advance our basic understanding… read more here.
Keywords: gaba glx; cbf; glx; fitness ... See more keywords
The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.967941
Abstract: Introduction Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on… read more here.
Keywords: glutamate; effect; antipsychotic treatment; glx ... See more keywords