Introduction of scaffold nitrogen atoms renders inhibitors of the malarial L-lactate transporter, PfFNT, effective against the Gly107Ser resistance mutation.
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DOI: 10.1021/acs.jmedchem.0c00852
Abstract: The spreading of malaria parasites, Plasmodium falciparum, with resistance to all known drugs calls for novel classes of inhibitors with new modes of action. Recently, we discovered and validated the plasmodial L-lactate transporter, PfFNT, as… read more here.
Keywords: transporter pffnt; gly107ser; pffnt; lactate transporter ... See more keywords