Assessment of the antidiabetic potentiality of glyburide loaded glyceryl monostearate solid lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.101451
Abstract: Abstract The high rate homogenisation techniques was used for preparing glyburide loaded glyceryl monostearate solid lipid nanoparticles (Glb-SLNs) to improve the drug's solubility and oral bioavailability. It was mediated through pseudo-ternary phase diagrams to optimize… read more here.
Keywords: glyceryl monostearate; glyburide loaded; glyburide; glb slns ... See more keywords
Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.116.074815
Abstract: Glyburide is widely used for the treatment of type 2 diabetes. We studied the mechanisms involved in the disposition of glyburide and its pharmacologically active hydroxy metabolites M1 and M2b and evaluated their clinical pharmacokinetics… read more here.
Keywords: clinical pharmacokinetics; disposition; transporter mediated; active metabolites ... See more keywords
Effects of Sulfonylureas on Periodontopathic Bacteria-Induced Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dental Research"
DOI: 10.1177/0022034520913250
Abstract: Interleukin-1β (IL-1β) is an inflammatory cytokine produced by monocytes/macrophages and is closely associated with periodontal diseases. The NLRP3 inflammasome is involved in IL-1β activation through pro–IL-1β processing and pyroptotic cell death in bacterial infection. Recently,… read more here.
Keywords: cell; bacteria induced; induced inflammation; glyburide ... See more keywords
Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s150043
Abstract: Glyburide (also known as glibenclamide) is a second-generation sulfonylurea drug that inhibits sulfonylurea receptor 1 (Sur1) at nanomolar concentrations. Long used to target KATP (Sur1–Kir6.2) channels for the treatment of diabetes mellitus type 2, glyburide… read more here.
Keywords: trpm4; large hemispheric; glyburide; edema ... See more keywords