Enabling Technologies in Carbohydrate Chemistry: Automated Glycan Assembly, Flow Chemistry and Data Science
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DOI: 10.1002/cbic.202200607
Abstract: The synthesis of defined oligosaccharides is a complex task. Several enabling technologies have been introduced in the last two decades to facilitate synthetic access to these valuable biomolecules. In this concept, we describe the technological… read more here.
Keywords: automated glycan; assembly flow; chemistry; glycan assembly ... See more keywords
Pushing the limits of automated glycan assembly: synthesis of a 50mer polymannoside.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04380e
Abstract: Automated glycan assembly (AGA) enables rapid access to oligosaccharides. The overall length of polymers created via automated solid phase synthesis depends on very high yields at every step to obtain full length products. The synthesis… read more here.
Keywords: limits automated; automated glycan; glycan assembly; pushing limits ... See more keywords
Automated glycan assembly of Streptococcus pneumoniae type 14 capsular polysaccharide fragments
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DOI: 10.1039/d0ra01803a
Abstract: S. pneumoniae is a major human pathogen with increasing antibiotic resistance. Pneumococcal vaccines consist of capsular polysaccharide (CPS) or their related fragments conjugated to a carrier protein. The repeating unit of S. pneumoniae type 14… read more here.
Keywords: pneumoniae type; automated glycan; glycan assembly; capsular polysaccharide ... See more keywords
Automated glycan assembly of highly branched heptadecasaccharide repeating unit of arabinogalactan polysaccharide HH1-1 from Carthamus tinctorius.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00687e
Abstract: Polysaccharides that are part of the human diet of fruits and vegetables influence the immune system via multiple signaling pathways. Given the immense complexity and diversity of naturally occurring polysaccharides and the difficulties associated isolating… read more here.
Keywords: automated glycan; heptadecasaccharide repeating; branched heptadecasaccharide; unit arabinogalactan ... See more keywords