Conformational Frustration at the Protein-Glycan Interface of a Nonmitogenic Anti-HIV Lectin Results in Altered Quaternary Structure.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical biology"
DOI: 10.1021/acschembio.5c00347
Abstract: Lectins are carbohydrate-binding proteins that have enormous therapeutic value because of their potent antiviral activity. However, the design of lectins for targeted intervention is marred by our poor understanding of protein-glycan recognition. Here, we focus… read more here.
Keywords: conformational frustration; quaternary structure; protein glycan; glycan interface ... See more keywords
Small-molecule compound from AlphaScreen disrupts tau-glycan interface
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1083225
Abstract: Tauopathies are neurodegenerative diseases characterized by intracellular abnormal tau deposits in the brain. Tau aggregates can propagate from one neuron to another in a prion-like manner, mediated by the interaction between tau and cell surface… read more here.
Keywords: small molecule; glycan interface; compound; interface ... See more keywords