Mass Spectrometry-based Shotgun Glycomics for Discovery of Natural Ligands of Glycan-binding Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c02931
Abstract: Glycans attached to lipids and membrane-bound and secreted proteins and peptides mediate many important physiological and pathophysiological processes through interactions with glycan-binding proteins (GBPs). However, uncovering functional glycan ligands is challenging due to the large… read more here.
Keywords: glycan binding; mass spectrometry; binding proteins; glycan ligands ... See more keywords
Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00560
Abstract: Multivalent interactions are a key characteristic of protein-carbohydrate recognition. Phospholipid-based liposomes have been explored as a popular platform for multivalent presentation of glycans, but this platform has been plagued by the instability of typical liposomal… read more here.
Keywords: glycan ligands; density; catanionic vesicles; carbohydrate ... See more keywords