Computational Modeling of Glycan Processing in the Golgi for Investigating Changes in the Arrangements of Biosynthetic Enzymes.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1685-7_10
Abstract: Modeling glycan biosynthesis is becoming increasingly important due to the far-reaching implications that glycosylation can exhibit, from pathologies to biopharmaceutical manufacturing. Here we describe a stochastic simulation approach, to overcome the deterministic nature of previous… read more here.
Keywords: processing golgi; glycan processing; computational modeling; investigating changes ... See more keywords
Suppression of N-glycan processing enzymes by deoxynojirimycin in tomato (Solanum lycopersicum) fruit
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02196-3
Abstract: The present study investigated the potential of a small molecule inhibitor, 1-deoxynojirimycin (DNJ), to extend the shelf life of tomatoes. The optimum concentration of DNJ and the proper ripening stage for treatment were standardized using… read more here.
Keywords: fruit; glycan processing; processing enzymes; treatment ... See more keywords
Inhibiting N-glycan processing increases the antibody binding affinity and effector function of human natural killer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13662
Abstract: Novel approaches are required to improve the efficacy of immunotherapies and increase the proportion of patients who experience a benefit. Antibody-dependent cell-mediated cytotoxicity (ADCC) contributes to the efficacy of many monoclonal antibodies therapies. Natural killer… read more here.
Keywords: cell; antibody binding; cd16a; glycan processing ... See more keywords
Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing
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DOI: 10.1126/sciadv.aax8930
Abstract: Kinetic analysis of intracellular intermediates affords a mathematical model for N-glycoprotein processing and secretion. N-linked glycosylation plays a fundamental role in determining the thermodynamic stability of proteins and is involved in multiple key biological processes.… read more here.
Keywords: secretion; processing; mechanistic reconstruction; glycan processing ... See more keywords
Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases
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DOI: 10.3390/biology11020199
Abstract: Simple Summary Glycans play many roles in biological processes. For instance, they mediate cell–cell interaction, viral infection, and protein folding of glycoproteins. Glycoprotein folding in the endoplasmic reticulum (ER) is closely related to the onset… read more here.
Keywords: type glycan; misfolding diseases; glycan processing; oligomannose type ... See more keywords
Glycoprotein In Vitro N-Glycan Processing Using Enzymes Expressed in E. coli
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062753
Abstract: Protein N-glycosylation is a common post-translational modification that plays significant roles on the structure, property, and function of glycoproteins. Due to N-glycan heterogeneity of naturally occurring glycoproteins, the functions of specific N-glycans on a particular… read more here.
Keywords: glycoprotein; vitro glycan; glycan processing; expressed coli ... See more keywords