Glycan Stability and Flexibility: Thermodynamic and Kinetic Characterization of Nonconventional Hydrogen Bonding in Lewis Antigens
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DOI: 10.1021/jacs.2c13104
Abstract: We provide evidence for CH-based nonconventional hydrogen bonds (H-bonds) for 10 Lewis antigens and two of their rhamnose analogues. We also characterize the thermodynamics and kinetics of the H-bonds in these molecules and present a… read more here.
Keywords: flexibility thermodynamic; lewis antigens; stability flexibility; glycan stability ... See more keywords
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design†‡
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DOI: 10.1039/d0sc04297h
Abstract: Single site OH → F substitution at the termini of maltotetraose leads to significantly improved hydrolytic stability towards α-amylase and α-glucosidase relative to the natural compound. To explore the effect of molecular editing, selectively modified… read more here.
Keywords: orientation; glycan stability; fluorination; site ... See more keywords