Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line
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DOI: 10.1080/19420862.2020.1844928
Abstract: ABSTRACT The heterogeneity of glycosylation on therapeutic monoclonal antibodies (mAbs) may affect the safety and efficacy of these agents. In particular, glycans of nonhuman origin, such as galactose-alpha-1,3-galactose (gal-α-gal) and N-glycolylneuraminic acid (NGNA), in the… read more here.
Keywords: glycans vivo; impact linked; antibody; vivo clearance ... See more keywords