Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a double-blind randomized controlled trial.
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DOI: 10.1002/jsfa.12346
Abstract: BACKGROUND Studies have shown that blue mussel lipid extract (BMLE) has strong anti-inflammatory activity in both rheumatoid arthritis patients and animal arthritis models. Chronic inflammation was closely related to type 2 diabetes mellitus (T2DM). While… read more here.
Keywords: blue mussel; bmle; trial; group ... See more keywords
Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population.
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DOI: 10.1016/j.gene.2018.07.066
Abstract: Insulin resistance and defects in other related glycemic traits are common findings in the context of Metabolic Syndrome. Although genetic factors are clearly implied in susceptibility, and some gene variants have been identified mainly in… read more here.
Keywords: insulin; variants ace; gene variants; glycemic traits ... See more keywords
Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits
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DOI: 10.1101/2022.07.26.22278077
Abstract: Background: Heterogeneity in the long-term metabolic response to dietary macronutrient composition can be partially explained by genetic factors. However, few studies have demonstrated reproducible gene-diet interactions (GDIs), likely due in part to measurement error in… read more here.
Keywords: diet interactions; genetic variants; gene diet; glycemic traits ... See more keywords
Elevated fasting insulin results in snoring: A view emerged from causal evaluation of glycemic traits and snoring
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DOI: 10.1111/eci.13852
Abstract: Snoring and impaired glucose metabolism are common clinical manifestations and associated. The purpose of our study is to estimate the causal associations between snoring and glycemic traits. read more here.
Keywords: elevated fasting; insulin results; fasting insulin; results snoring ... See more keywords
Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing
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DOI: 10.1186/s12929-025-01137-7
Abstract: Type 2 diabetes is an increasingly prevalent metabolic disorder with moderate to high heritability. Glycemic indices are crucial for diagnosing and monitoring the disease. Previous genome-wide association study (GWAS) have identified several risk loci associated… read more here.
Keywords: drug repurposing; genetics; type diabetes; glycemic traits ... See more keywords
Mendelian Randomization Suggests Causal Influence of Glycemic Traits on DNA Methylation
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DOI: 10.2337/db18-1707-p
Abstract: Type 2 diabetes (T2D) is caused by interactions between genetic predisposition and environmental exposure. DNA methylation, a key epigenetic mark, is one measure of the molecular impact of environmental factors on DNA. We tested for… read more here.
Keywords: methylation; cpg sites; mendelian randomization; glycemic traits ... See more keywords
Causal Graph Between Serum Lipids and Glycemic Traits: a Mendelian Randomization Study.
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DOI: 10.2337/db21-0734
Abstract: We systematically investigated the bidirectional causality between high-densitylipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), triglycerides (TG), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (sample size n =… read more here.
Keywords: causal graph; mendelian randomization; lipids glycemic; glycemic traits ... See more keywords
Evaluating the causal effect of circulating proteome on the glycemic traits: Evidence from Mendelian randomization.
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DOI: 10.2337/db24-0262
Abstract: Exploring the mechanisms underlying abnormal glycemic traits is important for deciphering type 2 diabetes and characterizing novel drug targets. This study aimed to decipher the causal associations of circulating proteins with fasting glucose (FG), 2-h… read more here.
Keywords: analysis; drug targets; glycemic traits; quantitative trait ... See more keywords
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
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DOI: 10.3389/fendo.2022.840579
Abstract: Objective We aimed to evaluate the causal effect of type 2 diabetes mellitus (T2DM) and glycemic traits on the risk of a wide range of cardiovascular diseases (CVDs) and lipid traits using Mendelian randomization (MR).… read more here.
Keywords: cardiovascular diseases; lipid traits; type diabetes; glycemic traits ... See more keywords
Causal associations between type 2 diabetes mellitus, glycemic traits, dietary habits and the risk of pressure ulcers: univariable, bidirectional and multivariable Mendelian randomization
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DOI: 10.3389/fnut.2024.1375179
Abstract: Objective Previous research has established a connection between Type 2 Diabetes Mellitus (T2DM), glycemic traits, dietary habits, and the risk of Pressure Ulcers (PUs). The aim of our study is to disentangle any potential causal… read more here.
Keywords: diabetes mellitus; type diabetes; risk; glycemic traits ... See more keywords