Transdermal delivery of glyceryl trinitrate: clinical applications in acute stroke
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2020.1716727
Abstract: ABSTRACT Introduction Glyceryl trinitrate (GTN), a nitric oxide donor, is a candidate treatment for the management of acute stroke with hemodynamic and potential reperfusion and neuroprotective effects. Areas covered Here we discuss the evidence to… read more here.
Keywords: glyceryl trinitrate; delivery; gtn; acute stroke ... See more keywords
Contactless skin perfusion monitoring with video cameras: tracking pharmacological vasoconstriction and vasodilation using photoplethysmographic changes
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Measurement"
DOI: 10.1088/1361-6579/ac9c82
Abstract: Objectives. Clinical assessment of skin perfusion informs prognosis in critically ill patients. Video camera monitoring could provide an objective, continuous method to monitor skin perfusion. In this prospective, interventional study of healthy volunteers, we tested… read more here.
Keywords: video cameras; glyceryl trinitrate; perfusion; colour ... See more keywords
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain"
DOI: 10.1093/brain/awy177
Abstract: Glyceryl trinitrate administration causes prolonged mechanical allodynia in rodents, which correlates temporally with delayed migraine attacks in patients. Marone et al. show that the allodynia is mediated by TRPA1 activation in cell bodies of trigeminal… read more here.
Keywords: glyceryl trinitrate; trpa1 nox; nox soma; soma trigeminal ... See more keywords
Endocrine disruption: Reproductive toxicity of glyceryl trinitrate and isosorbide mononitrate in male Wistar rats
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14482
Abstract: Glyceryl trinitrate (GTN) and isosorbide mononitrate (IM) are organic nitrates which release nitric oxide upon metabolism with potential to adversely affect male reproductive function. Therefore, this study was designed to evaluate the sub‐chronic effect of… read more here.
Keywords: glyceryl trinitrate; wistar rats; isosorbide mononitrate;
Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage
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DOI: 10.1161/strokeaha.119.026389
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: trinitrate ultra; acute intracerebral; prehospital transdermal; ultra acute ... See more keywords
Is Glyceryl Trinitrate, a Nitric Oxide Donor Responsible for Ameliorating the Chemical-Induced Tissue Injury In Vivo?
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144362
Abstract: Oxidative stress induced by well-known toxins including ferric nitrilotriacetate (Fe-NTA), carbon tetrachloride (CCl4) and thioacetamide (TAA) has been attributed to causing tissue injury in the liver and kidney. In this study, the effect of glyceryl… read more here.
Keywords: effect; nitric oxide; glyceryl trinitrate; gtn ... See more keywords