Backbone chemical shift assignments of the glycine cleavage complex H protein of Escherichia coli
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DOI: 10.1007/s12104-018-9801-z
Abstract: Glycine cleavage complex H protein (GcvH) is one of the four components that form the glycine cleavage complex (GCS), essential for the synthesis of C1 (one-carbon units) for cell metabolism, by the oxidative cleavage of… read more here.
Keywords: cleavage; escherichia coli; complex protein; glycine cleavage ... See more keywords
Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes
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DOI: 10.1111/pcn.12628
Abstract: Hypofunction of N‐methyl‐D‐aspartate receptors (NMDAR) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia, the… read more here.
Keywords: mutations glycine; glycine cleavage; cleavage system; system genes ... See more keywords
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
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DOI: 10.26508/lsa.201900413
Abstract: The glycine cleavage system (GCS) is highly activated to promote stem cell pluripotency. The GCS catabolizes glycine to prevent methylglyoxal accumulation and to fuel H3K4me3 modification, promoting the expression of pluripotency genes. Metabolic remodelling has… read more here.
Keywords: stem; glycine cleavage; pluripotency; cleavage system ... See more keywords