Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114607
Abstract: Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo[a]pyrene,… read more here.
Keywords: hepatocellular carcinoma; liver disorders; liver; glycine methyltransferase ... See more keywords
Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22298-6
Abstract: Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role… read more here.
Keywords: glycine methyltransferase; increasing cyp3a44; induced nephropathy; gnmt ... See more keywords
MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30682-5
Abstract: Glycine N-methyltransferase (GNMT) is a tumor suppressor for HCC. It is down-regulated in HCC, but the mechanism is not fully understood. MicroRNA-224 (miR-224) acts as an onco-miR in HCC. This study is the first to… read more here.
Keywords: mir 224; microrna 224; expression; gnmt ... See more keywords
S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin-proteasome system.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2417821122
Abstract: Significance S-adenosylmethionine (SAM) metabolism is crucial for diverse functions, mediated through methylation. Although the feedback regulation of SAM production has been explored extensively, our understanding of the mechanism behind SAM consumption remains incomplete. Constant levels… read more here.
Keywords: sam; nuclear ubiquitin; glycine methyltransferase; proteasome system ... See more keywords
Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production
Sign Up to like & getrecommendations! Published in 2019 at "Aging Cell"
DOI: 10.1111/acel.13043
Abstract: Reduced insulin/IGF signaling (IIS) extends lifespan in multiple organisms. Different processes in different tissues mediate this lifespan extension, with a set of interplays that remain unclear. We here show that, in Drosophila, reduced IIS activity… read more here.
Keywords: insulin; longevity; gnmt; glycine methyltransferase ... See more keywords
Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Reports"
DOI: 10.14814/phy2.14576
Abstract: Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the… read more here.
Keywords: fibrosis; targeted untargeted; glycine methyltransferase; immune function ... See more keywords
Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Gastroenterology"
DOI: 10.20524/aog.2018.0288
Abstract: The methionine and folate cycles play a fundamental role in cell physiology and their alteration is involved in liver injury and hepatocarcinogenesis. Glycine N-methyltransferase is implicated in methyl group supply, DNA methylation, and nucleotide biosynthesis.… read more here.
Keywords: methyltransferase; physiology; role; liver injury ... See more keywords