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Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.11034
Abstract: Glycine receptors (GlyRs) belong to the family of ligand‐gated cys‐loop receptors and effectuate fast inhibitory neurotransmission in central nervous system (CNS). They are involved in numerous physiological processes, such as movement, respiration, and processing of…
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Keywords:
neuronal damage;
glycine receptors;
glucose deficiency;
oxygen glucose ... See more keywords
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Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1607-3
Abstract: The neurons in the trigeminal mesencephalic nucleus (Vmes) innervate jaw-closing muscle spindles and periodontal ligaments, and play a crucial role in the regulation of jaw movements. Recently, it was shown that many boutons that form…
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Keywords:
trigeminal mesencephalic;
mesencephalic nucleus;
homomeric glycine;
glycine receptors ... See more keywords
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Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.024
Abstract: Postsynaptic scaffold proteins immobilise neurotransmitter receptors in the synaptic membrane opposite to presynaptic vesicle release sites, thus ensuring efficient synaptic transmission. At inhibitory synapses in the spinal cord, the main scaffold protein gephyrin assembles in…
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Keywords:
inhibitory synapses;
scaffold proteins;
glycine receptors;
gephyrin ... See more keywords
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Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107773
Abstract: Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have been implicated in the release of dopamine from the ventral…
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Keywords:
glycine receptors;
medium spiny;
spiny neurons;
nucleus accumbens ... See more keywords
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Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01496
Abstract: Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activation…
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Keywords:
tricyclic sulfonamides;
lead optimization;
glycine receptors;
optimization ... See more keywords
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Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00050
Abstract: Glycine receptors (GlyRs) are members of the pentameric ligand-gated ionic channel family (pLGICs) and mediate fast inhibitory neurotransmission in the brain stem and spinal cord. The function of GlyRs can be modulated by positive allosteric…
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Keywords:
intracellular domain;
allosteric modulators;
sensitivity;
glycine receptors ... See more keywords
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Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2021.2016746
Abstract: Although a number of studies have reported that resveratrol has analgesic effects, the direct effect of resveratrol on substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) involved in orofacial nociceptive transmission has not…
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Keywords:
inward currents;
glycine receptors;
gelatinosa neurons;
substantia gelatinosa ... See more keywords
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Published in 2019 at "Addiction Biology"
DOI: 10.1111/adb.12726
Abstract: Alcohol abuse leads to great medical, social, and economic burdens throughout the world. It is believed that the rewarding actions of alcohol are mediated by alterations in the mesolimbic dopaminergic system leading to increased levels…
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Keywords:
influence nonsynaptic;
place preference;
glycine receptors;
ethanol ... See more keywords
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Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15649
Abstract: BACKGROUND AND PURPOSE Previous studies showed that glycine receptors (GlyRs) composed of α1 and β subunits are primarily found in spinal cord and brainstem and are potentiated by ethanol (10-100 mM). However, much less is…
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Keywords:
tegmental area;
presence;
ventral tegmental;
glycine receptors ... See more keywords
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Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01941-y
Abstract: Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations contribute to cognitive and motor impairment. Activation of glycine receptors is…
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Keywords:
hyperammonemic rats;
neuroinflammation;
extracellular cgmp;
glycine receptors ... See more keywords
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Published in 2022 at "Current vascular pharmacology"
DOI: 10.2174/1570161120666220720101352
Abstract: Glycine Receptors (GlyRs) are cell-surface transmembrane proteins that belong to the Cys-loop ligand-gated ion channels superfamily (Cys-loop LGICs). Functional glycine receptors are conformed only by α-subunits (homomeric channels) or by α- and β-subunits (heteromeric channels).…
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Keywords:
glycine;
post ischemic;
glycine receptors;
role glycine ... See more keywords