P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2
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DOI: 10.1016/j.neuropharm.2017.07.018
Abstract: Glycinergic inhibitory neurons of the spinal dorsal horn exert critical control over the conduction of nociceptive signals to higher brain areas. The neuronal glycine transporter 2 (GlyT2) is involved in the recycling of synaptic glycine… read more here.
Keywords: p2x; glycine transporter; expression; neuronal glycine ... See more keywords
Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia
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DOI: 10.1016/j.schres.2016.10.027
Abstract: OBJECTIVE To determine the safety and efficacy of AMG 747, an oral inhibitor of glycine transporter type-1 (GlyT1), as an add-on to antipsychotic therapy in clinically stable people with schizophrenia with enduring negative symptoms. METHOD… read more here.
Keywords: glycine transporter; negative symptoms; treatment; amg 747 ... See more keywords