Endothelial Glycocalyx.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210029
Abstract: The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is primarily conformed of glycoproteins and proteoglycans, which provide communication, electrostatic charge, ionic buffering, permeability, and mechanosensation-mechanotransduction capabilities to cells.… read more here.
Keywords: physiology; blood; degradation; glycocalyx ... See more keywords
Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12290
Abstract: Abstract Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity. Available methods to improve the tissue… read more here.
Keywords: extracellular vesicles; evs; specificity; glycocalyx ... See more keywords
Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-022-01854-w
Abstract: In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS)… read more here.
Keywords: glycocalyx; heparan sulfate; ext1 ext2; endothelial glycocalyx ... See more keywords
Attenuating Pulmonary Hypertension by Protecting the Integrity of Glycocalyx in Rats Model of Pulmonary Artery Hypertension
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01055-5
Abstract: The endothelial glycocalyx has been proved to be a polysaccharide protein complex covering the surface of vascular endothelial cells, playing an important role in vascular permeability, blood flow shear stress induction, and prevention of endothelial… read more here.
Keywords: protecting integrity; pulmonary hypertension; integrity glycocalyx; glycocalyx ... See more keywords
Kawasaki disease and increased cardiovascular risk: Is there a link to circulating glycocalyx biomarkers?
Sign Up to like & getrecommendations! Published in 2021 at "Microvascular research"
DOI: 10.1016/j.mvr.2021.104269
Abstract: AIMS Kawasaki disease (KD) is an acute systemic vasculitis with possible long-term impact of general cardio-vascular health. An endothelial glycocalyx disorder during the disease's acute phase might predispose to long-term vascular anomalies leading to endothelial… read more here.
Keywords: acute phase; glycocalyx; cardiovascular risk; blood ... See more keywords
209. The microvascular endothelial glycocalyx: impaired barrier function in preeclampsia with small gestational age neonates
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.294
Abstract: Introduction The glycocalyx, the endothelial lining of membrane-bound proteoglycans and glycoproteins, serves as a functional barrier between flowing red blood cells (RBC) and the endothelial cell membrane. Recent studies suggest that damage to the glycocalyx,… read more here.
Keywords: small gestational; glycocalyx; gestational age; function ... See more keywords
Accessing and Assessing the Cell-Surface Glycocalyx Using DNA Origami
Sign Up to like & getrecommendations! Published in 2021 at "Nano Letters"
DOI: 10.1021/acs.nanolett.1c01236
Abstract: The cell-surface glycocalyx serves as a physiological barrier regulating cellular accessibility to macromolecules and other cells. Conventional glycocalyx characterization has largely been morphological rather than functional. Here, we demonstrated direct glycocalyx anchoring of DNA origami… read more here.
Keywords: origami; dna; glycocalyx; cell surface ... See more keywords
Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries.
Sign Up to like & getrecommendations! Published in 2019 at "Faraday discussions"
DOI: 10.1039/c9fd00024k
Abstract: In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular interactions.… read more here.
Keywords: glycocalyx; evaluate molecular; glycocalyx structures; spectator glycocalyx ... See more keywords
Effect of electric-double layer on the blood flow in glycocalyx layered tubes: applications to drug delivery in microvessels
Sign Up to like & getrecommendations! Published in 2020 at "Fluid Dynamics Research"
DOI: 10.1088/1873-7005/abcb9a
Abstract: Role of endothelium glycocalyx integraty is important for targeted intravenous nanoparticle drug delivery. It plays a vital role in many physical functions in microvessel including protection of the vessel wall with harmful levels of fluid… read more here.
Keywords: blood flow; layer; glycocalyx layer; glycocalyx ... See more keywords
The predictive role of endothelial glycocalyx in primary prevention of cardiovascular events:a 6 year follow-up study
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3780
Abstract: Endothelial glycocalyx is a layer of glycoproteins on endothelial cells preventing vascular wall permeability to circulating proteins and blood cells. Perfused Boundary Region (PBR) of arterial microvessel is a non-invasive marker of endothelial glycocalyx thickness,… read more here.
Keywords: risk; glycocalyx; pbr; endothelial glycocalyx ... See more keywords
Endothelial glycocalyx—the battleground for complications of sepsis and kidney injury
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfx076
Abstract: After briefly discussing endothelial glycocalyx and its role in vascular physiology and renal disease, this overview focuses on its degradation very early in the course of microbial sepsis. We describe our recently proposed mechanism for… read more here.
Keywords: glycocalyx; glycocalyx battleground; battleground complications; sepsis kidney ... See more keywords