Resuscitation fluids as drugs: targeting the endothelial glycocalyx
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DOI: 10.1097/cm9.0000000000001869
Abstract: Abstract Fluid resuscitation is an essential intervention in critically ill patients, and its ultimate goal is to restore tissue perfusion. Critical illnesses are often accompanied by glycocalyx degradation caused by inflammatory reactions, hypoperfusion, shock, and… read more here.
Keywords: glycocalyx degradation; fluids drugs; restore glycocalyx; resuscitation fluids ... See more keywords
PULMONARY VASCULAR ENDOTHELIAL GLYCOCALYX DEGRADATION CONTRIBUTES TO ACUTE LUNG INJURY IN EXPERIENCING HEATSTROKE
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DOI: 10.1097/shk.0000000000002130
Abstract: ABSTRACT Objectives: This study investigated the role and potential involvement of pulmonary vascular glycocalyx degradation in acute lung injury in rats with severe heatstroke (HS). Methods: Rats in an established HS model were exposed to… read more here.
Keywords: glycocalyx degradation; lung injury; lung; pulmonary vascular ... See more keywords
Endothelial Glycocalyx Degradation in Critical Illness and Injury
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DOI: 10.3389/fmed.2022.898592
Abstract: The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is composed of glycosaminoglycans and the proteins that tether them to the plasma membrane. Interest in its properties and function… read more here.
Keywords: glycocalyx degradation; degradation critical; injury; glycocalyx ... See more keywords
Circulating concentrations of glycocalyx degradation products in preeclampsia
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DOI: 10.3389/fphys.2022.1022770
Abstract: Background and Objectives: Preeclampsia is a multisystem disorder that affects maternal endothelium. The glycocalyx lines and protects the endothelial surface. In severe systemic diseases, like sepsis, it is shed and glycocalyx degradation products can be… read more here.
Keywords: glycocalyx degradation; end organ; organ complications; women preeclampsia ... See more keywords