Sterile filtration of a multi‐serotype glycoconjugate vaccine drug product
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28342
Abstract: Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens. Previous studies of the sterile filtration behavior of these glycoconjugates have been limited to experiments… read more here.
Keywords: sterile filtration; drug; drug product; glycoconjugate ... See more keywords
Pt(II) versus Pt(IV) in Carbene Glycoconjugate Antitumor Agents: Minimal Structural Variations and Great Performance Changes
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.9b03683
Abstract: Octahedral Pt(IV) complexes (2Pt–R) containing a glycoconjugate carbene ligand were prepared and fully characterized. These complexes are structural analogues to the trigonal bipyramidal Pt(II) species (1Pt–R) recently described. Thus, an unprecedented direct comparison between the… read more here.
Keywords: glycoconjugate antitumor; glycoconjugate; versus carbene; carbene glycoconjugate ... See more keywords
A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08805h
Abstract: A new fluorescence-forming probe, coumOCT, designed by fusing cyclooctyne with a coumarin fluorophore was successfully used for the imaging of azido-glycoconjugates in living HeLa cells. This probe is cell-permeable and generates fluorescence after triazole formation,… read more here.
Keywords: forming fluorescent; cell permeable; probe; glycoconjugate ... See more keywords
Immunogenicity of a Glycoconjugate from Hydrazine‐Detoxified Lipopolysaccharide of Vibrio cholerae O139
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12623
Abstract: A glycoconjugate (dLPS‐CBSA) from hydrazine‐detoxified lipopolysaccharide (LPS) of Vibrio cholerae O139 and BSA was used for immunization of BALB/c mice. The immunogenicity (concentration of induced IgG antibodies) of the conjugate was determined by enzyme‐linked immunosorbent… read more here.
Keywords: vibrio cholerae; cholerae; glycoconjugate; hydrazine detoxified ... See more keywords
Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9120774
Abstract: Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccharides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier… read more here.
Keywords: mechanism pneumococcal; glycoconjugate vaccines; glycoconjugate; conjugation mechanism ... See more keywords