Prefiltration enhances performance of sterile filtration for glycoconjugate vaccines
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Progress"
DOI: 10.1002/btpr.3180
Abstract: Recent studies have reported very low capacity during sterile filtration of glycoconjugate vaccines due to rapid fouling of the sterile filter. The objective of this study was to explore the potential for significantly increasing the… read more here.
Keywords: sterile filter; filtration; size; glycoconjugate vaccines ... See more keywords
Interplay of Carbohydrate and Carrier in Antibacterial Glycoconjugate Vaccines.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in biochemical engineering/biotechnology"
DOI: 10.1007/10_2018_71
Abstract: Bacterial infections are a serious health concern and are responsible for millions of illnesses and deaths each year in communities around the world. Vaccination is an important public health measure for reducing and eliminating this… read more here.
Keywords: carbohydrate carrier; interplay carbohydrate; carrier; glycoconjugate vaccines ... See more keywords
Improving efficacy of glycoconjugate vaccines: from chemical conjugates to next generation constructs.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2020.03.015
Abstract: Glycoconjugate vaccines are among the safest and most successful vaccines developed during the past 30 years. Since the first semisynthetic chemical conjugate vaccine licensed in the 1980's to protect human against Haemophilus influenzae type b… read more here.
Keywords: improving efficacy; efficacy glycoconjugate; chemical; glycoconjugate vaccines ... See more keywords
Glycan and Protein Analysis of Glycoengineered Bacterial E. coli Vaccines by MALDI-in-Source Decay FT-ICR Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.1c04690
Abstract: Bacterial glycoconjugate vaccines have a major role in preventing microbial infections. Immunogenic bacterial glycans, such as O-antigen polysaccharides, can be recombinantly expressed and combined with specific carrier proteins to produce effective vaccines. O-Antigen polysaccharides are… read more here.
Keywords: source decay; glycoconjugate vaccines; mass spectrometry; analysis ... See more keywords
Synthetic Glycans to Improve Current Glycoconjugate Vaccines and Fight Antimicrobial Resistance
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DOI: 10.1021/acs.chemrev.2c00021
Abstract: Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile, Escherichia coli, Enterococcus faecium, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, non-typhoidal Salmonella, and Staphylococcus aureus, and… read more here.
Keywords: synthetic glycans; antimicrobial resistance; glycoconjugate vaccines; glycans improve ... See more keywords
Recent Advances in Lipopolysaccharide-Based Glycoconjugate Vaccines.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of vaccines"
DOI: 10.1080/14760584.2021.1984889
Abstract: INTRODUCTION The public health burden caused by pathogenic Gram-negative bacteria is increasingly prominent due to antimicrobial resistance. The surface carbohydrates are potential antigens for vaccines against Gram-negative bacteria. The enhanced immunogenicity of the O-specific polysaccharide… read more here.
Keywords: lps based; gram negative; vaccines recent; glycoconjugate vaccines ... See more keywords
Potential targets for next generation antimicrobial glycoconjugate vaccines
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuy011
Abstract: Abstract Cell surface carbohydrates have been proven optimal targets for vaccine development. Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune response to the glycan moiety. Licensed glycoconjugate vaccines are produced by chemical… read more here.
Keywords: targets next; generation antimicrobial; potential targets; glycoconjugate vaccines ... See more keywords
Glycoconjugate vaccines: Principles and mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat4615
Abstract: Insight into the mechanisms of glycoconjugate vaccines can improve their efficacy and impact in the future. Bacterial conjugate vaccines are used in infants, adolescents, and the elderly, and they are among the safest and most… read more here.
Keywords: medicine; mechanisms glycoconjugate; vaccines principles; principles mechanisms ... See more keywords
Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Cell Factories"
DOI: 10.1186/s12934-021-01588-1
Abstract: Protein Glycan Coupling Technology (PGCT) uses purposely modified bacterial cells to produce recombinant glycoconjugate vaccines. This vaccine platform holds great potential in this context, namely due to its modular nature, the simplified production process in… read more here.
Keywords: automated platform; production; process; platform ... See more keywords
Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
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DOI: 10.3390/bioengineering9120774
Abstract: Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccharides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier… read more here.
Keywords: mechanism pneumococcal; glycoconjugate vaccines; glycoconjugate; conjugation mechanism ... See more keywords
Carriers and Antigens: New Developments in Glycoconjugate Vaccines
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11020219
Abstract: Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines. Glycoconjugate vaccines consist… read more here.
Keywords: vaccines carriers; glycoconjugate vaccines; antigens new; new developments ... See more keywords