Fast and Ultrasensitive Glycoform Analysis by Supercritical Fluid Chromatography–Tandem Mass Spectrometry
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DOI: 10.1021/acs.analchem.2c01721
Abstract: The glycoform of a therapeutic monoclonal antibody (mAb) has a significant impact on its effector function as well as its safety and pharmacokinetics. Glycoform heterogeneity is influenced by various factors, including the producing cells and… read more here.
Keywords: chromatography tandem; fluid chromatography; supercritical fluid; glycoform ... See more keywords
Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry
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DOI: 10.1021/jacs.1c02713
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes an extensively glycosylated surface spike (S) protein to mediate host cell entry, and the S protein glycosylation plays key roles in altering the viral binding/function and infectivity.… read more here.
Keywords: spectrometry; heterogeneity; glycoform; spike protein ... See more keywords