Maintenance of liver glycogen during long‐term fasting preserves energy state in mice
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13770
Abstract: Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during… read more here.
Keywords: energy state; glycogen; mice; liver glycogen ... See more keywords
Inadequate brain glycogen or sleep increases spreading depression susceptibility
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25122
Abstract: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional changes in astrocytes, reducing glycogen breakdown. We hypothesize that… read more here.
Keywords: brain glycogen; sleep increases; glycogen sleep; glycogen ... See more keywords
Glycogen at the Crossroad of Stress Resistance, Energy Maintenance, and Pathophysiology of Aging
Sign Up to like & getrecommendations! Published in 2018 at "BioEssays"
DOI: 10.1002/bies.201800033
Abstract: Glycogen is synthesized and stored to maintain postprandial blood glucose homeostasis and to ensure an uninterrupted energy supply between meals. Although the regulation of glycogen turnover has been well studied, the effects of glycogen on… read more here.
Keywords: energy; glycogen crossroad; crossroad stress; glycogen ... See more keywords
Production of 1,2‐propanediol in photoautotrophic Synechocystis is linked to glycogen turn‐over
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26468
Abstract: We utilized a photoautotrophic organism to synthesize 1,2‐propanediol from carbon dioxide and water fueled by light. A synthetic pathway comprising mgsA (methylglyoxal synthase), yqhD (aldehyde reductase), and adh (alcohol dehydrogenase) was inserted into Synechocystis sp.… read more here.
Keywords: synechocystis; production propanediol; production; glycogen ... See more keywords
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia open"
DOI: 10.1002/epi4.12599
Abstract: Glucose is the main brain fuel in fed conditions, while astrocytic glycogen is used as supplemental fuel when the brain is stimulated. Brain glycogen levels are decreased after induced seizures in rodents, but little is… read more here.
Keywords: epilepsy; glycogen levels; model; glycogen ... See more keywords
Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29751
Abstract: Genetic variation at rs4240624 on chromosome 8 is associated with an attenuated signal on hepatic computerized tomography, which has been attributed to changes in hepatic fat. The closest coding gene to rs4240624, PPP1R3B, encodes a… read more here.
Keywords: hepatic glycogen; ppp1r3b; glycogen; genetic variation ... See more keywords
Hepatic ChREBP activation limits NAFLD development in a mouse model for Glycogen Storage Disease type Ia.
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31198
Abstract: Glycogen storage disease type Ia (GSD Ia) is an inborn error of metabolism caused by defective glucose-6-phosphatase (G6PC) activity. GSD Ia patients exhibit severe hepatomegaly due to glycogen and triglyceride (TG) accumulation in the liver.… read more here.
Keywords: storage; glycogen; disease; nafld development ... See more keywords
Lysosomal glycogen accumulation in Pompe disease results in disturbed cytoplasmic glycogen metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12560
Abstract: Pompe disease is an inherited metabolic myopathy caused by deficiency of acid alpha‐glucosidase (GAA), resulting in lysosomal glycogen accumulation. Residual GAA enzyme activity affects disease onset and severity, although other factors, including dysregulation of cytoplasmic… read more here.
Keywords: lysosomal glycogen; disease; cytoplasmic glycogen; pompe disease ... See more keywords
Does shuttling of glycogen‐derived lactate from astrocytes to neurons take place during neurotransmission and memory consolidation?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24387
Abstract: Glycogen levels in resting brain and its utilization rates during brain activation are high, but the functions fulfilled by glycogenolysis in living brain are poorly understood. Studies in cultured astrocytes have identified glycogen as the… read more here.
Keywords: glycogen derived; glycogen; derived lactate; neurotransmission ... See more keywords
Noradrenaline‐induced l‐lactate production requires d‐glucose entry and transit through the glycogen shunt in single‐cultured rat astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24783
Abstract: During cognitive efforts mediated by local neuronal networks, approximately 20% of additional energy is required; this is mediated by chemical messengers such as noradrenaline (NA). NA targets astroglial aerobic glycolysis, the hallmark of which is… read more here.
Keywords: transit glycogen; glycogen; lactate production; glycogen shunt ... See more keywords
Activation of the IGF1 receptor stimulates glycogen synthesis by mink uterine epithelial cells
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DOI: 10.1002/mrd.22981
Abstract: Glycogen synthesis by mink uterine epithelial cells is stimulated by estradiol (E2) during estrus, although the mechanism/s through which the steroid promotes glycogen accumulation are unknown. Our aim was to determine if insulin is required… read more here.
Keywords: insulin; glycogen synthesis; uterine epithelial; glycogen ... See more keywords