Lysosomal glycogen accumulation in Pompe disease results in disturbed cytoplasmic glycogen metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12560
Abstract: Pompe disease is an inherited metabolic myopathy caused by deficiency of acid alpha‐glucosidase (GAA), resulting in lysosomal glycogen accumulation. Residual GAA enzyme activity affects disease onset and severity, although other factors, including dysregulation of cytoplasmic… read more here.
Keywords: lysosomal glycogen; disease; cytoplasmic glycogen; pompe disease ... See more keywords
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment.
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DOI: 10.1016/j.cmet.2017.06.008
Abstract: Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of glycogen in striated muscle. Furthermore,… read more here.
Keywords: muscle; glycogen; accumulation muscle; lack glycogenin ... See more keywords
Glycogen Accumulation Induces the Hippo Pathway and Liver Tumorigenesis.
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DOI: 10.1158/2159-8290.cd-rw2021-154
Abstract: Glycogen is a key oncogenic metabolite in liver tumor initiation. read more here.
Keywords: glycogen accumulation; accumulation induces; glycogen; pathway liver ... See more keywords
Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.819440
Abstract: Astrocytic glycogen plays an important role in brain energy metabolism. However, the contribution of glycogen metabolism to stress-induced depression remains unclear. Chronic social defeat stress was used to induce depression-like behaviors in mice, assessed with… read more here.
Keywords: depression; glycogen accumulation; stress induced; glycogen ... See more keywords