Discovery of novel α‐carboline derivatives as glycogen synthase kinase‐3β inhibitors for the treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200156
Abstract: Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss, and behavioral disturbances, ultimately resulting in death. The critical roles of glycogen synthase kinase‐3β (GSK‐3β) in tau pathology… read more here.
Keywords: disease; alzheimer disease; carboline derivatives; glycogen synthase ... See more keywords
Icaritin and icariin reduce p-Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2114
Abstract: AIMS This study aimed to explore the neuroprotective effect of icariin/icaritin (ICA/ICT) and the role of ICA/ICT in the treatment of Alzheimer's disease (AD). METHODS ICA and ICT were used to treat okadaic acid (OA)-induced… read more here.
Keywords: glycogen synthase; tau; ica ict; alzheimer disease ... See more keywords
Knockdown of glycogen phosphorylase and glycogen synthase influences expression of chitin synthesis genes of rice brown planthopper Nilaparvata lugens
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asia-Pacific Entomology"
DOI: 10.1016/j.aspen.2019.06.006
Abstract: Abstract Glycogen synthase (GS) and glycogen phosphorylase (GP) are two key enzymes in the glycogen synthesis pathway, which catalyze trehalose and glucose transformation in insects. GS and GP can be regulated by trehalose metabolism, which… read more here.
Keywords: glycogen phosphorylase; chitin; chitin synthesis; glycogen ... See more keywords
Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.02.020
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes swelling, bone erosion, and joint disorder. Patients with RA therefore suffer from pain and physiological disability, and have a decreased quality of life. During… read more here.
Keywords: glycogen synthase; kinase; anti rheumatoid; synthase kinase ... See more keywords
Natural and synthetic bioactive inhibitors of glycogen synthase kinase.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.058
Abstract: Glycogen synthase kinase-3 is a multi-functional serine-threonine kinase and is involved in diverse physiological processes, including metabolism, cell cycle, and gene expression by regulating a wide variety of known substrates like glycogen synthase, tau-protein and… read more here.
Keywords: natural synthetic; glycogen synthase; synthase kinase; synthetic bioactive ... See more keywords
Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.103
Abstract: Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and signalling pathways. It exists in two isoforms, GSK-3α and GSK-3β and can… read more here.
Keywords: kinase inhibitors; glycogen synthase; kinase; target ... See more keywords
Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.05.080
Abstract: Abstract The aerial parts of Lamiaceae plants have been used since ancient times all over the world, especially in Mediterranean cultures, for their medicinal and culinary properties. Although some of them have a historical role… read more here.
Keywords: kinase; anti alzheimer; alzheimer effects; potential anti ... See more keywords
Chlamydia trachomatis glycogen synthase promotes MAPK-mediated proinflammatory cytokine production via TLR2/TLR4 in THP-1 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119181
Abstract: AIMS To investigate the roles and mechanisms of C. trachomatis glycogen synthase (GlgA) in regulating the inflammatory response in THP-1 cells. MAIN METHODS In this work, after THP-1 cells were stimulated with GlgA, transcript and… read more here.
Keywords: glycogen synthase; trachomatis glycogen; tlr2 tlr4; thp cells ... See more keywords
The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva)
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry international"
DOI: 10.1016/j.neuint.2019.104603
Abstract: Glycogen synthase kinase 3 (GSK-3) is a constitutively active multifunctional serine-threonine kinase which is involved in diverse physiological processes. GSK-3 has been implicated in a wide range of diseases including neurodegeneration, inflammation, diabetes and cancer.… read more here.
Keywords: glycogen synthase; kinase; kinase gsk; synthase kinase ... See more keywords
Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.07.006
Abstract: ABSTRACT Cerebral stroke is a leading cause of early death and physical disability in adults throughout the world. Oxidative stress and inflammation plays an important role in the pathological process associated with the stroke. The… read more here.
Keywords: management; glycogen synthase; cerebral stroke; oxidative stress ... See more keywords
Reduction of dopamine and glycogen synthase kinase-3 signaling in rat striatum after continuous administration of haloperidol
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2021.173114
Abstract: BACKGROUND Some individuals with schizophrenia present with a dopamine supersensitivity state (DSS) induced by a long-term administration of excessive antipsychotics; this is recognized as dopamine supersensitivity psychosis (DSP). The mechanisms underlying DSP are not established.… read more here.
Keywords: administration; glycogen synthase; dopamine; synthase kinase ... See more keywords