Polymer conjugation optimizes EDTA as a calcium-chelating agent that exclusively removes extrafibrillar minerals from mineralized collagen.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.04.011
Abstract: During development of mineralized collagenous tissues, intrafibrillar mineralization is achieved by preventing mineralization precursor inhibitors that are larger than 40 kDa from entering the collagen fibrils. Such a property is incorporated in the design of a… read more here.
Keywords: collagen; dentin; glycol chitosan; calcium ... See more keywords
Glycol chitosan-based renal docking biopolymeric nanomicelles for site-specific delivery of the immunosuppressant.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.116255
Abstract: In this study, we propose the use of glycol chitosan for the targeted delivery of hydrophobic drugs such as tacrolimus (TAC) towards the kidney. We synthesized a hydrophobically modified glycol chitosan (HGC) polymeric nanomicelle followed… read more here.
Keywords: tac; delivery; glycol chitosan; hgc tac ... See more keywords
Injectable glycol chitosan thermogel formulation for efficient inner ear drug delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118969
Abstract: We prepared a new injectable thermogel to enhance the efficiency of inner ear delivery of dexamethasone (DEX). Hexanoyl glycol chitosan (HGC) was synthesized and evaluated as an amphiphilic thermogel (Tgel ~ 32 °C) for use as a solubilizing… read more here.
Keywords: inner ear; drug delivery; drug; ear drug ... See more keywords
Glycol chitosan/iron oxide/polypyrrole nanoclusters for precise chemodynamic/photothermal synergistic therapy.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.085
Abstract: Noninvasive photothermal therapy (PTT) represents a promising direction for more modern and precise medical applications. However, PTT efficacy is still not satisfactory due to the existence of heat shock proteins (HSPs) and poorly targeted delivery.… read more here.
Keywords: polypyrrole nanoclusters; iron oxide; therapy; synergistic therapy ... See more keywords
Thermosensitive glycol chitosan-based hydrogel as a topical ocular drug delivery system for enhanced ocular bioavailability.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118688
Abstract: In the present study, we developed and evaluated an in situ gelling system based on hexanoyl glycol chitosan (H-GCS) for enhanced ocular bioavailability. An aqueous solution of H-GCS exhibited a typical sol-gel transition at 32… read more here.
Keywords: glycol chitosan; gcs hydrogel; system; ocular bioavailability ... See more keywords
Carbon dots intensified poly (ethylene glycol)/chitosan/sodium glycerophosphate hydrogel as artificial synovium tissue with slow-release lubricant.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2018.08.024
Abstract: The ultra-high molecular weight polyethylene (UHMWPE) and metal artificial joint pair is limited by wear debris and short service life. Here we report the development of a hydrogel which exhibits lubricant release to intensify the… read more here.
Keywords: hydrogel; carbon dots; poly ethylene; ethylene glycol ... See more keywords
Design and Synthesis of Stem Cell-Laden Keratin/Glycol Chitosan Methacrylate Bioinks for 3D Bioprinting.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00191
Abstract: With the advancements in tissue engineering and three-dimensional (3D) bioprinting, physiologically relevant three-dimensional structures with suitable mechanical and bioactive properties that mimic the biological tissue can be designed and fabricated. However, the available bioinks are… read more here.
Keywords: cell; methacrylate; keratin; chitosan methacrylate ... See more keywords
Highly Sensitive Colorimetric Assay for Determining Fe3+ Based on Gold Nanoparticles Conjugated with Glycol Chitosan
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2017/3648564
Abstract: A highly sensitive and simple colorimetric assay for the detection of Fe3+ ions was developed using gold nanoparticles (AuNPs) conjugated with glycol chitosan (GC). The Fe3+ ion coordinates with the oxygen atoms of GC in… read more here.
Keywords: gold nanoparticles; colorimetric assay; highly sensitive; conjugated glycol ... See more keywords
Corrigendum: Preparation and characterization of polyethylene glycol/chitosan composite water-based wound healing lubricant
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1191529
Abstract: [This corrects the article DOI: 10.3389/fbioe.2022.990249.]. read more here.
Keywords: preparation characterization; characterization polyethylene; chitosan composite; polyethylene glycol ... See more keywords
Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24234371
Abstract: Glycol chitosan (GC), a water-soluble chitosan derivative with hydrophilic ethylene glycol branches, has both hydrophobic segments for the encapsulation of various drugs and reactive functional groups for facile chemical modifications. Over the past two decades,… read more here.
Keywords: glycol chitosan; delivery; chitosan water; water soluble ... See more keywords
A Unique Core–Shell Structured, Glycol Chitosan-Based Nanoparticle Achieves Cancer-Selective Gene Delivery with Reduced Off-Target Effects
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020373
Abstract: The inherent instability of nucleic acids within serum and the tumor microenvironment necessitates a suitable vehicle for non-viral gene delivery to malignant lesions. A specificity-conferring mechanism is also often needed to mitigate off-target toxicity. In… read more here.
Keywords: core; core shell; glycol chitosan; unique core ... See more keywords