Further evidence in favour of a carbanion mechanism for glycolate oxidase
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DOI: 10.1002/2211-5463.13534
Abstract: The flavoenzyme glycolate oxidase oxidizes glycolic acid to glyoxylate and the latter, more slowly, to oxalate. It is a member of an FMN‐dependent enzyme family that oxidizes l‐2‐hydroxy acids to keto acids. There has been… read more here.
Keywords: glycolate oxidase; oxidase; evidence; carbanion ... See more keywords
Application of Rhodococcus jostii RHA1 glycolate oxidase as an efficient accessory enzyme for lignin conversion by bacterial Dyp peroxidase enzymes
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DOI: 10.1039/d3gc00475a
Abstract: Lignin oxidation by bacterial dye-decolorizing peroxidase enzymes requires hydrogen peroxide as a co-substrate, an unstable and corrosive oxidant. We have identified a glycolate oxidase enzyme from Rhodococcus jostii RHA1 that can couple effectively at pH… read more here.
Keywords: rhodococcus jostii; glycolate oxidase; jostii rha1; peroxidase enzymes ... See more keywords
Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening
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DOI: 10.3389/fchem.2022.844598
Abstract: Primary hyperoxaluria type I (PH1) is caused by AGXT gene mutations that decrease the functional activity of alanine:glyoxylate aminotransferase. A build-up of the enzyme’s substrate, glyoxylate, results in excessive deposition of calcium oxalate crystals in… read more here.
Keywords: glycolate oxidase; crystallography; fragment screening; oxidase ... See more keywords
Evolution of Photorespiratory Glycolate Oxidase among Archaeplastida
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DOI: 10.3390/plants9010106
Abstract: Photorespiration has been shown to be essential for all oxygenic phototrophs in the present-day oxygen-containing atmosphere. The strong similarity of the photorespiratory cycle in cyanobacteria and plants led to the hypothesis that oxygenic photosynthesis and… read more here.
Keywords: glycolate oxidase; oxidase; gox; photorespiratory glycolate ... See more keywords