The type 1 transmembrane glycoprotein B7‐H3 interacts with the glycolytic enzyme ENO1 to promote malignancy and glycolysis in HeLa cells
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DOI: 10.1002/1873-3468.13164
Abstract: The role of the type 1 transmembrane glycoprotein B7‐H3 is controversial in tumorigenesis; thus, a better clarification of its involvement in cancer is crucial. In the present study, 79.3% of cervical cancer samples were found… read more here.
Keywords: glycolysis; type transmembrane; transmembrane glycoprotein; hela ... See more keywords
Glycolysis, via NADH‐dependent dimerisation of CtBPs, regulates hypoxia‐induced expression of CAIX and stem‐like breast cancer cell survival
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DOI: 10.1002/1873-3468.13874
Abstract: Adaptive responses to hypoxia are mediated by the hypoxia‐inducible factor (HIF) family of transcription factors. These responses include the upregulation of glycolysis to maintain ATP production. This also generates acidic metabolites, which require HIF‐induced carbonic… read more here.
Keywords: glycolysis; breast cancer; expression; cancer ... See more keywords
Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer
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DOI: 10.1002/1878-0261.12629
Abstract: Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis,… read more here.
Keywords: glycolysis; pkm2; colorectal cancer; 122 pkm2 ... See more keywords
Comparative metabolomics and glycolysis enzyme profiling of embryogenic and nonembryogenic grape cells
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DOI: 10.1002/2211-5463.12415
Abstract: A novel biological model was created for the comparison of grapevine embryogenic cells (EC) and nonembryogenic cells (NEC) sharing a common genetic background but distinct phenotypes, when cultured on their respective most appropriate media. Cytological… read more here.
Keywords: glycolysis; enzyme profiling; glycolysis enzyme; comparative metabolomics ... See more keywords
Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment
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DOI: 10.1002/2211-5463.12628
Abstract: Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy… read more here.
Keywords: inhibition glycolysis; glycolysis; hepg2 cells; antioxidant defense ... See more keywords
Metabolic Cycles in Cancer Cells?
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DOI: 10.1002/bies.202000048
Abstract: Obviously the EMBO/EMBL Symposium “Metabolism Meets Epigenetics” left more of an impression on me than at first I thought; perhaps that was inevitable given the enormously wide range of biological phenomena that are starting to… read more here.
Keywords: glycolysis; metabolic cycle; metabolic cycles; cancer cells ... See more keywords
Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer
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DOI: 10.1002/cam4.1587
Abstract: Development of neuroendocrine prostate cancer (NEPC) is emerging as a major problem in clinical management of advanced prostate cancer (PCa). As increasingly potent androgen receptor (AR)‐targeting antiandrogens are more widely used, PCa transdifferentiation into AR‐independent… read more here.
Keywords: secretion; glycolysis; prostate cancer; acid ... See more keywords
METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma
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DOI: 10.1002/cam4.2918
Abstract: METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular… read more here.
Keywords: hepatocellular carcinoma; hcc; glycolysis; mettl3 ... See more keywords
MiR‐5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer
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DOI: 10.1002/cam4.3344
Abstract: Gastric cancer (GC) is one of the most deadly malignancies at global scale, and is particularly common in eastern Asia. MicroRNA‐5683 (miR‐5683) was confirmed to be downregulated in GC by analyzing data from the Cancer… read more here.
Keywords: glycolysis; mir 5683; gastric cancer; mir ... See more keywords
The long noncoding RNA HOXA11‐AS promotes lung adenocarcinoma proliferation and glycolysis via the microRNA‐148b‐3p/PKM2 axis
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DOI: 10.1002/cam4.5103
Abstract: Lung cancer is the most common malignancy in the world and a growing number of researches have focused on its metabolic characteristics. Studies have shown that the long non‐coding RNA (lncRNA) HOXA11‐AS is aberrantly expressed… read more here.
Keywords: lung adenocarcinoma; rna; long noncoding; glycolysis ... See more keywords
CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells.
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DOI: 10.1002/cbin.11778
Abstract: The incidence of gliomas is increasing. Although great progress in glioma treatment has been made, the clinical outcome remains unsatisfactory. Chemokine (C-C motif) ligand 2 (CCL2) plays a key role in different types of cancers,… read more here.
Keywords: glycolysis; chemoresistance; ccl2; glioma ... See more keywords