254 CTLA-4 blockade promotes Treg glucose metabolism and reduces Treg functional stability in glycolysis-defective tumors
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DOI: 10.1136/jitc-2020-sitc2020.0254
Abstract: Background Durable clinical responses to immune checkpoint blockade (ICB) occur in a limited fraction of patients. We thus hypothesized that the characteristic tumor metabolic switch towards aerobic glycolysis could contribute to ICB resistance. High glucose… read more here.
Keywords: glycolysis defective; ctla blockade; glycolysis; tumor ... See more keywords