Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2022.04.022
Abstract: Cancer cells rely on glycolysis to support a high proliferation rate. Metformin (Met) is a promising drug for tumor treatment that targets hexokinase 2 (HK2) to block the glycolytic process, thereby further disrupting the metabolism… read more here.
Keywords: therapy; glycolysis inhibition; gox; cancer ... See more keywords
Effect of mitochondrial uncoupling and glycolysis inhibition on ram sperm functionality
Sign Up to like & getrecommendations! Published in 2017 at "Reproduction in Domestic Animals"
DOI: 10.1111/rda.12901
Abstract: Studies have demonstrated the importance of mitochondria to sperm functionality, as the main source of ATP for cellular homoeostasis and motility. However, the role of mitochondria on sperm metabolism is still controversial. Studies indicate that,… read more here.
Keywords: ram sperm; glycolysis inhibition; sperm functionality; glycolysis ... See more keywords
Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis-infected preterm newborns.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.157234
Abstract: Preterm infants are susceptible to bloodstream infection by coagulase-negative staphylococci (CONS) that can lead to sepsis. High parenteral glucose supplement is commonly used to support their growth and energy expenditure, but may exceed endogenous regulation… read more here.
Keywords: glycolysis inhibition; staphylococcus epidermidis; infection; glucose supply ... See more keywords
Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurosurgery"
DOI: 10.3171/2018.12.jns181798
Abstract: OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity… read more here.
Keywords: glioma; glycolysis inhibition; glioma radiosensitivity; mir 448 ... See more keywords