The contribution of ketone bodies to glycolytic inhibition for the treatment of adult and pediatric glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03431-w
Abstract: Purpose Glioblastoma (GBM) remains one of the most lethal primary brain tumors in children and adults. Targeting tumor metabolism has emerged as a promising-targeted therapeutic strategy for GBM and characteristically resistant GBM stem-like cells (GSCs).… read more here.
Keywords: gbm; treatment; ketone; adult pediatric ... See more keywords
Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics.
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DOI: 10.1007/s11357-020-00298-7
Abstract: Calorie restriction mimetics encompass a growing research field directed toward developing treatments that mimic the anti-aging effects of long-term calorie restriction without requiring a change in eating habits. A wide range of approaches have been… read more here.
Keywords: restriction; calorie restriction; restriction mimetics; strategy ... See more keywords
Exploiting metabolic susceptibilities in glioblastoma via glycolytic inhibition and ketogenic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e13558
Abstract: e13558 Background: Glioblastoma (GBM) remains one of the most lethal primary brain tumors in children and adults. Despite enormous efforts to elucidate the genetic and epigenetic drivers of this disease, the prognosis for patients diagnosed… read more here.
Keywords: metabolic susceptibilities; glycolytic inhibition; cell; inhibition ... See more keywords