Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.023
Abstract: Cancer-associated fibroblasts (CAFs) play a critical role in cancer progression, metastasis, and therapy resistance. Molecular events that confer CAF-phenotype to predecessor-cells are not fully understood. We demonstrate here that the ovarian cancer cell-conditioned medium (OCC-CM)… read more here.
Keywords: glycolytic shift; ovarian cancer; lpa; cancer cell ... See more keywords
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac073
Abstract: ABSTRACT Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been established in pulmonary hypertension (PH). However, the effect of elevated mROS on glycolytic shift and how increased glycolysis promotes hypoxic pulmonary artery smooth muscle… read more here.
Keywords: promotes hypoxic; pulmonary hypertension; glycolytic shift; lactylation ... See more keywords
Abstract 2405: P53-dependent mitophagy controls glycolytic shift in radioresistant head and neck cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2405
Abstract: P53 is an important biomarker in response to genotoxic stress, but it is also known to plays a key role in the regulation of metabolic homeostasis. The loss of p53 is a well-established contributor to… read more here.
Keywords: neck cancer; glycolytic shift; cancer; p53 ... See more keywords