The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant Glioma
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DOI: 10.3390/ijms22115518
Abstract: Malignant glioma represents a fatal disease with a poor prognosis and development of resistance mechanisms against conventional therapeutic approaches. The distinct tumor zones of this heterogeneous neoplasm develop their own microenvironment, in which subpopulations of… read more here.
Keywords: microenvironment; malignant glioma; glycolytic switch; switch ... See more keywords
The Glycolytic Switch in Tumors: How Many Players Are Involved?
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DOI: 10.7150/jca.21125
Abstract: Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient oxygen is available. This reliance on aerobic glycolysis is called… read more here.
Keywords: tumors many; glycolytic switch; switch; switch tumors ... See more keywords
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential
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DOI: 10.7150/thno.51631
Abstract: Objectives: Mesenchymal Stem/Stromal Cells (MSC) are promising therapeutic tools for inflammatory diseases due to their potent immunoregulatory capacities. Their suppressive activity mainly depends on inflammatory cues that have been recently associated with changes in MSC… read more here.
Keywords: atp synthase; glycolytic switch; dependent glycolytic; ampk dependent ... See more keywords