Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00121g
Abstract: The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a… read more here.
Keywords: type lectin; cov spike; lectin receptors; glycomimetic ligands ... See more keywords