Bioinspired and Inflammation‐Modulatory Glycopeptide Hydrogels for Radiation‐Induced Chronic Skin Injury Repair
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201671
Abstract: Clinical wound management of radiation‐induced skin injury (RSI) remains a great challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and the concomitant repetitive inflammatory microenvironment caused by an imbalance in macrophage… read more here.
Keywords: glycopeptide; inflammation; skin injury; radiation induced ... See more keywords
A Dynamic Membrane‐Active Glycopeptide for Enhanced Protection of Human Red Blood Cells against Freeze‐Stress
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202516
Abstract: Intracellular delivery of freezing‐tolerant trehalose is crucial for cryopreservation of red blood cells (RBCs) and previous strategies based on membrane‐disruptive activity usually generate severe hemolysis. Herein, a dynamic membrane‐active glycopeptide is developed by grafting with… read more here.
Keywords: dynamic membrane; glycopeptide; red blood; blood cells ... See more keywords
Glycopeptide characterization of Sf9‐derived SARS‐CoV‐2 spike protein recombinant vaccine candidates expedited by the use of glycopeptide libraries
Sign Up to like & getrecommendations! Published in 2022 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.9452
Abstract: Rationale We report the N‐glycosylation pattern of Sf9 insect cell‐derived recombinant spike proteins being developed as candidate vaccine antigens for SARS‐CoV‐2 (COVID‐19) (Sanofi). The method has been optimised to produce peptides with single, isolated glycosylation… read more here.
Keywords: glycopeptide; glycopeptide libraries; spike protein; use glycopeptide ... See more keywords
Multifaceted antibodies development against synthetic α-dystroglycan mucin glycopeptide as promising tools for dystroglycanopathies diagnostic
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09893-z
Abstract: Dystroglycanopathies are diseases characterized by progressive muscular degeneration and impairment of patient’s quality of life. They are associated with altered glycosylation of the dystrophin-glycoprotein (DGC) complex components, such as α-dystroglycan (α-DG), fundamental in the structural… read more here.
Keywords: monoclonal antibodies; development synthetic; antibodies development; multifaceted antibodies ... See more keywords
A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of Aβ42.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03823
Abstract: The fruit of Fructus Mori is food and medicine, which has been demonstrated to have a significant neuroprotective effect. However, the effective constituent remains unknown. We speculate that the glycopeptide in the extract of the… read more here.
Keywords: glycopeptide; fruit fructus; pectin like; fruit ... See more keywords
Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03245
Abstract: Natural products are the greatest source of antimicrobial agents, although their structural complexity often renders synthetic production and diversification of key classes impractical. One pertinent example is the glycopeptide antibiotics (GPAs), which are highly challenging… read more here.
Keywords: evaluate tricyclization; precursor peptides; enzymatic cascade; cascade evaluate ... See more keywords
Enzymatic Formation of an Injectable Hydrogel from a Glycopeptide as a Biomimetic Scaffold for Vascularization.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b18535
Abstract: The construction of functional vascular networks in regenerative tissues is a crucial technology in tissue engineering to ensure the sufficient supply of nutrients. Although natural hydrogels are highly prevalent in fabricating three-dimensional scaffolds to induce… read more here.
Keywords: injectable hydrogel; hydrogel; formation injectable; enzymatic formation ... See more keywords
Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics.
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DOI: 10.2174/1568026617666170130115957
Abstract: INTRODUCTION The increased resistance of glycopeptide based antibiotics has become a serious problem for the chemotherapy of infections triggered by resistant Gram-positive bacteria. This has motivated the urgent sincere efforts to develop potent glycopeptide-based antibiotics… read more here.
Keywords: mechanism action; synthesis properties; glycopeptide antibiotics; polycyclic glycopeptide ... See more keywords
What Is the Most Effective Empirical Antibiotic Treatment for Early, Delayed, and Late Fracture-Related Infections?
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DOI: 10.3390/antibiotics11030287
Abstract: Antibiotic treatment strategies for fracture-related infections (FRI) are often extrapolated from periprosthetic joint infections (PJI), although, in contrast to PJI, detailed analysis of pathogens and their antibiotic resistance is missing. Therefore, this study aimed to… read more here.
Keywords: vancomycin; glycopeptide; early delayed; antibiotic treatment ... See more keywords