Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway
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DOI: 10.1002/cbic.202000309
Abstract: The glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core coupled to a cytochrome P450‐mediated cyclisation cascade that crosslinks aromatic side chains within this… read more here.
Keywords: crosslinking cascade; biosynthesis; antibiotic crosslinking; cascade ... See more keywords
The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03530j
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DOI: 10.1039/c8sc03530j
Abstract: The condensation domain synthesising the last peptide bond in glycopeptide antibiotic biosynthesis has a preference for linear peptide substrates, with effective peptide formation linked to the rate of amino acid activation by the preceding adenylation… read more here.
Keywords: antibiotic biosynthesis; condensation domain; glycopeptide antibiotic;
New Molecular Tools for Regulation and Improvement of A40926 Glycopeptide Antibiotic Production in Nonomuraea gerenzanensis ATCC 39727
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DOI: 10.3389/fmicb.2020.00008
Abstract: Genome sequencing has revealed that Nonomuraea spp. represent a still largely unexplored source of specialized metabolites. Nonomuraea gerenzanensis ATCC 39727 is the most studied representative species since it produces the glycopeptide antibiotic (GPA) A40926 –… read more here.
Keywords: production; gerenzanensis; gerenzanensis atcc; a40926 ... See more keywords