Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.6b00820
Abstract: A review of efforts that have provided total syntheses of vancomycin and related glycopeptide antibiotics, their agylcons, and key analogues is provided. It is a tribute to developments in organic chemistry and the field of… read more here.
Keywords: total syntheses; vancomycin related; key analogues; related glycopeptide ... See more keywords
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10384-w
Abstract: Kistamicin is a divergent member of the glycopeptide antibiotics, a structurally complex class of important, clinically relevant antibiotics often used as the last resort against resistant bacteria. The extensively crosslinked structure of these antibiotics that… read more here.
Keywords: production; biosynthesis reveals; reveals biosynthetic; kistamicin biosynthesis ... See more keywords
A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics.
Sign Up to like & getrecommendations! Published in 2017 at "MedChemComm"
DOI: 10.1039/c6md00585c
Abstract: Cell wall biosynthesis inhibitors (CBIs) have historically been one of the most effective classes of antibiotics. They are the most extensively used class of antibiotics and their importance is exemplified by the β-lactams and glycopeptide… read more here.
Keywords: inhibitors emphasis; review cell; cell wall; glycopeptide antibiotics ... See more keywords
Next-generation membrane-active glycopeptide antibiotics that also inhibit bacterial cell division
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05600c
Abstract: Resistance to vancomycin, a life-saving drug against Gram-positive bacterial infections necessitates developing alternative therapeutics. Herein, we report vancomycin derivatives that assimilate mechanisms beyond d-Ala–d-Ala binding. The role of hydrophobicity towards the structure and function of… read more here.
Keywords: cell; glycopeptide antibiotics; cell division; bacterial cell ... See more keywords
Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026617666170130115957
Abstract: INTRODUCTION The increased resistance of glycopeptide based antibiotics has become a serious problem for the chemotherapy of infections triggered by resistant Gram-positive bacteria. This has motivated the urgent sincere efforts to develop potent glycopeptide-based antibiotics… read more here.
Keywords: mechanism action; synthesis properties; glycopeptide antibiotics; polycyclic glycopeptide ... See more keywords
Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12040641
Abstract: Teicoplanin and A40926 (natural precursor of dalbavancin) are clinically relevant glycopeptide antibiotics (GPAs) produced by Actinoplanes teichomyceticus NRRL B-16726 and Nonomuraea gerenzanensis ATCC 39727. Their biosynthetic enzymes are coded within large biosynthetic gene clusters (BGCs),… read more here.
Keywords: pathway specific; glycopeptide antibiotics; teicoplanin a40926; gerenzanensis ... See more keywords