Synthetic Glycopeptides Allow for the Quantitation of Scarce Nonfucosylated IgG Fc N-Glycans of Therapeutic Antibody.
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DOI: 10.1021/acsmedchemlett.8b00127
Abstract: Glycans attached to the IgG Fc domain affect strongly biological activities such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) of therapeutic antibodies. However, molecular mechanism in the glycoform-dependent functional modulation of the IgGs… read more here.
Keywords: quantitation scarce; glycopeptides allow; igg glycans; antibody ... See more keywords