Binding Modes of a Glycopeptidomimetic Molecule on Aβ Protofibrils: Implication for Its Inhibition Mechanism.
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DOI: 10.1021/acschemneuro.8b00341
Abstract: We recently reported that a glycopeptidomimetic molecule significantly delays the fibrillization process of Aβ42 peptide involved in Alzheimer's disease. However, the binding mode of this compound, named 3β, was not determined at the atomic scale,… read more here.
Keywords: glycopeptidomimetic molecule; binding modes; inhibition mechanism; mechanism ... See more keywords