Computational analysis of BACE1-ligand complex crystal structures and linear discriminant analysis for identification of BACE1 inhibitors with anti P-glycoprotein binding property
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DOI: 10.1080/07391102.2016.1276477
Abstract: More than 100 years of research on Alzheimer’s disease didn’t yield a potential cure for this dreadful disease. Poor Blood Brain Barrier (BBB) permeability and P-glycoprotein binding of BACE1 inhibitors are the major causes for… read more here.
Keywords: bace1 inhibitors; bace1 ligand; analysis; glycoprotein binding ... See more keywords