Assessment of verdinexor as a canine P-glycoprotein substrate.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.13123
Abstract: The P-glycoprotein (P-gp) substrate status of antineoplastic drugs intended for veterinary patients is an important characteristic to define for two reasons. First, neoplastic cells expressing P-gp can actively efflux drugs that are P-gp substrates curtailing… read more here.
Keywords: verdinexor; canine; antineoplastic drugs; glycoprotein substrate ... See more keywords
Transepithelial transport of P-glycoprotein substrate by the Malpighian tubules of the desert locust
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223569
Abstract: Extrusion of xenobiotics is essential for allowing animals to remove toxic substances present in their diet or generated as a biproduct of their metabolism. By transporting a wide range of potentially noxious substrates, active transporters… read more here.
Keywords: malpighian tubules; tubules desert; desert locust; glycoprotein ... See more keywords