Synthesis, α-glycosidase inhibitory potential and molecular docking study of benzimidazole derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103555
Abstract: A series of twenty-six analogs of benzimidazole based oxadiazole have been synthesized and evaluated against alpha-glycosidase enzyme. Most the analogs showed excellent to good inhibitory potential. Among the screened analogs, analog 1, 2, 3 and… read more here.
Keywords: glycosidase inhibitory; inhibitory potential; docking study; synthesis glycosidase ... See more keywords
A synthesis of tiruchanduramine and a reinvestigation of its glycosidase inhibitory activity
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.06.008
Abstract: Abstract Tiruchanduramine 1 was prepared using a convergent strategy with the longest linear sequence being eight steps. Synthetic 1, displayed a broader range of inhibition than reported previously and, in addition to α-glucosidases, 1 also… read more here.
Keywords: tiruchanduramine; glycosidase inhibitory; synthesis tiruchanduramine; tiruchanduramine reinvestigation ... See more keywords
The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis
Sign Up to like & getrecommendations! Published in 2019 at "Current Organic Synthesis"
DOI: 10.2174/1570179416666190126100312
Abstract: Background: The inherent glycosidase inhibitory activity and potentially therapeutic value of the polyhydroxylated pyrrolizidine alkaloids containing a hydroxymethyl substituent at the C-3 position have been well documented. Belonging to this class, the naturally occurring hyacinthacine… read more here.
Keywords: type alkaloids; hyacinthacine type; glycosidase inhibitory; synthesis ... See more keywords
Pentacyclic Triterpenoids from Sabia discolor Dunn and Their α-Glycosidase Inhibitory Activities
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DOI: 10.3390/molecules27072161
Abstract: Four new pentacyclic triterpenoids named Sabiadiscolor A–D (1 and 7–9) together with eleven known ones were isolated by repeated column chromatography. Their structures were identified and characterized by NMR and MS spectral data as 6… read more here.
Keywords: sabia discolor; pentacyclic triterpenoids; discolor dunn; glycosidase inhibitory ... See more keywords