A modified glycosylase base editor without predictable DNA off‐target effects
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DOI: 10.1002/1873-3468.14970
Abstract: Glycosylase base editor (GBE) can induce C‐to‐G transversion in mammalian cells, showing great promise for the treatment of human genetic disorders. However, the limited efficiency of transversion and the possibility of off‐target effects caused by… read more here.
Keywords: dna target; target effects; glycosylase base; base editor ... See more keywords