Mass spectrometry for the identification and analysis of highly complex glycosylation of therapeutic or pathogenic proteins
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2020.1769479
Abstract: ABSTRACT Introduction Protein glycosylation influences characteristics such as folding, stability, protein interactions, and solubility. Therefore, glycan moieties of therapeutic proteins and proteins that are likely associated with disease pathogenesis should be analyzed in-depth, including glycan… read more here.
Keywords: mass spectrometry; glycosylated proteins; analysis; glycosylation ... See more keywords
GLYCO: a tool to quantify glycan shielding of glycosylated proteins
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DOI: 10.1093/bioinformatics/btab791
Abstract: MOTIVATION Glycans play important roles in protein folding and cell-cell interactions-and, furthermore, glycosylation of protein antigens can dramatically impact immune responses. While there have been attempts to quantify the glycan shielding or coverage of a… read more here.
Keywords: glycan shielding; shielding glycosylated; quantify glycan; protein surface ... See more keywords