Enhanced glycosylation of an S‐layer protein enables a psychrophilic methanogenic archaeon to adapt to elevated temperatures in abundant substrates
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13650
Abstract: Adaptation to higher temperatures would increase the environmental competitiveness of psychrophiles, organisms that thrive in low‐temperature environments. Methanolobus psychrophilus, a cold wetland methanogen, ‘evolved’ as a mesophile, growing optimally at 30 °C after subculturings, and… read more here.
Keywords: glycosylation layer; glycosylation; layer protein; archaeon ... See more keywords
N‐glycosylation and expression in human tissues of the orphan GPR61 receptor
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DOI: 10.1002/2211-5463.12339
Abstract: A number of members of the G protein‐coupled receptor class of cell surface receptors are ‘orphans’ with no known endogenous ligand. One of these orphan receptors is GPR61; there are little data about its expression… read more here.
Keywords: gpr61; expression human; glycosylation; expression ... See more keywords
DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice
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DOI: 10.1002/advs.202000531
Abstract: Abstract Post‐translational modification of proteins by N‐linked glycosylation is crucial for many life processes. However, the exact contribution of N‐glycosylation to mammalian female reproduction remains largely undefined. Here, DPAGT1, the enzyme that catalyzes the first… read more here.
Keywords: indispensable oocyte; protein glycosylation; dpagt1; glycosylation ... See more keywords
N‐glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer
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DOI: 10.1002/advs.202411740
Abstract: Liver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N‐glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N‐glycosylation proteomics associated with liver… read more here.
Keywords: colorectal cancer; crc; glycosylation modification; metastasis ... See more keywords
Core Fucosylation Represses SMURF1-Dependent Degradation of CD47 to Promote Tumor Immune Evasion.
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DOI: 10.1002/advs.202516863
Abstract: Glycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor immune escape. However,… read more here.
Keywords: tumor immune; tumor; cd47; core fucosylation ... See more keywords
First Total Synthesis of Inaoside A
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DOI: 10.1002/ajoc.202400547
Abstract: The first total synthesis of inaoside A, an α‐D‐ribofuranoside isolated by our group from the edible mushroom Laetiporus cremeiporus, is described. The key reaction was an α‐selective Schmidt glycosylation. Most reported syntheses of ribofuranosides following… read more here.
Keywords: synthesis inaoside; total synthesis; first total; glycosylation ... See more keywords
FKRP directed fibronectin glycosylation: A novel mechanism giving insights into muscular dystrophies?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100270
Abstract: The recently uncovered role of Fukutin‐related protein (FKRP) in fibronectin glycosylation has challenged our understanding of the basis of disease pathogenesis in the muscular dystrophies. FKRP is a Golgi‐resident glycosyltransferase implicated in a broad spectrum… read more here.
Keywords: muscular dystrophies; fibronectin glycosylation; directed fibronectin; dystrophies fkrp ... See more keywords
An integrated modular framework for modeling the effect of ammonium on the sialylation process of monoclonal antibodies produced by CHO cells
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DOI: 10.1002/biot.202100019
Abstract: Monoclonal antibodies (mABs) have emerged as one of the most important therapeutic recombinant proteins in the pharmaceutical industry. Their immunogenicity and therapeutic efficacy are influenced by post‐translational modifications, specifically the glycosylation process. Bioprocess conditions can… read more here.
Keywords: integrated modular; modular framework; monoclonal antibodies; process ... See more keywords
Toward Machine Learning‐Guided CHO Bioprocess and Media Optimization for Improved Titer and Glycosylation
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DOI: 10.1002/biot.70149
Abstract: Precise control of critical quality attributes, including titer and glycosylation, is essential in bioprocessing, yet conventional design‑of‑experiments methods are challenged by the high‐dimensional, nonlinear design space for media and process parameters. We assemble a comprehensive… read more here.
Keywords: process; toward machine; machine learning; titer glycosylation ... See more keywords
N‐glycan engineering of a plant‐produced anti‐CD20‐hIL‐2 immunocytokine significantly enhances its effector functions
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DOI: 10.1002/bit.26503
Abstract: Anti‐CD20 recombinant antibodies are among the most promising therapeutics for the treatment of B‐cell malignancies such as non‐Hodgkin lymphomas. We recently demonstrated that an immunocytokine (2B8‐Fc‐hIL2), obtained by fusing an anti‐CD20 scFv‐Fc antibody derived from… read more here.
Keywords: plant; effector functions; glycosylation; anti cd20 ... See more keywords
Probabilistic model by Bayesian network for the prediction of antibody glycosylation in perfusion and fed‐batch cell cultures
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DOI: 10.1002/bit.27769
Abstract: Glycosylation is a critical quality attribute of therapeutic monoclonal antibodies (mAbs). The glycan pattern can have a large impact on the immunological functions, serum half‐life and stability. The medium components and cultivation parameters are known… read more here.
Keywords: network; bayesian network; glycosylation; perfusion fed ... See more keywords