MHC haplotype and B cell autoimmunity: correlation with pathogenic IgG autoantibody subclasses and Fc glycosylation patterns.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149279
Abstract: Genome-wide association studies (GWAS) have identified many genes that are associated with the development of certain autoimmune disorders, but the major histocompatibility complex (MHC) haplotypes still represent the most prevalent genetic risk factor for many… read more here.
Keywords: mhc haplotype; igg; pathogenic igg; cell autoimmunity ... See more keywords
Comparative Glycopeptide Analysis for Protein Glycosylation by Liquid Chromatography and Tandem Mass Spectrometry: Variation in Glycosylation Patterns of Site-Directed Mutagenized Glycoprotein
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2018/8605021
Abstract: Glycosylation is one of the most important posttranslational modifications for proteins, including therapeutic antibodies, and greatly influences protein physiochemical properties. In this study, glycopeptide mapping of a reference and biosimilar recombinant antibodies (rAbs) was performed… read more here.
Keywords: mass spectrometry; mass; tandem mass; glycosylation ... See more keywords
IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03166
Abstract: Preterm infants acquire reduced amounts of Immunoglobulin G (IgG) via trans-placental transfer as compared to term infants which might explain their high susceptibility for infections. The reduced amount of IgG antibodies also results in a… read more here.
Keywords: igg glycosylation; glycosylation patterns; preterm infants; patterns preterm ... See more keywords
Distinct N-Linked Immunoglobulin G Glycosylation Patterns Are Associated With Chronic Pathology and Asymptomatic Infections in Human Lymphatic Filariasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.790895
Abstract: Lymphatic filariasis presents a complex spectrum of clinical manifestations ranging from asymptomatic microfilariaemic (MF+) to chronic pathology (CP), including lymphedema and elephantiasis. Emerging evidence suggests a link between the physiopathology of filarial infections and antibody… read more here.
Keywords: pathology; lymphatic filariasis; chronic pathology; glycosylation patterns ... See more keywords
Lectins as Biomarkers of IC/BPS Disease: A Comparative Study of Glycosylation Patterns in Human Pathologic Urothelium and IC/BPS Experimental Models
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12051078
Abstract: Pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains poorly understood, as well as its effective diagnosis and therapy. Studying changes in tissue glycosylation patterns under pathological conditions is a promising way of discovering novel biomarkers… read more here.
Keywords: experimental models; urothelium bps; bps; glycosylation patterns ... See more keywords
Potential Novel N-Glycosylation Patterns Associated with the Emergence of New Genetic Variants of PRRSV-2 in the U.S
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10122021
Abstract: Glycosylation of proteins is a post-translational process where oligosaccharides are attached to proteins, potentially altering their folding, epitope availability, and immune recognition. In Porcine reproductive and respiratory syndrome virus-type 2 (PRRSV-2), positive selection pressure acts… read more here.
Keywords: potential novel; prrsv; novel glycosylation; glycosylation ... See more keywords