Controlling the Glycosylation Profile in mAbs Using Time-Dependent Media Supplementation
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DOI: 10.3390/antib7010001
Abstract: In order to meet desired drug product quality targets, the glycosylation profile of biotherapeutics such as monoclonal antibodies (mAbs) must be maintained consistently during manufacturing. Achieving consistent glycan distribution profiles requires identifying factors that influence… read more here.
Keywords: supplementation; time; glycosylation profile; profile mabs ... See more keywords
Longitudinal Pathogenic Properties and N-Glycosylation Profile of Antibodies from Patients with Pemphigus after Corticosteroid Treatment
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DOI: 10.3390/biomedicines9101411
Abstract: Pemphigus vulgaris is an autoimmune disease that occurs due to pathogenic autoantibodies that recognize the following epidermal adhesion proteins: desmogleins. Systemic corticosteroids usually decrease the titers of anti-desmoglein autoantibodies and improve patients’ conditions. Since modifications… read more here.
Keywords: pathogenic activity; longitudinal pathogenic; glycosylation profile; pathogenic properties ... See more keywords
Anandamide-Modulated Changes in Metabolism, Glycosylation Profile and Migration of Metastatic Melanoma Cells
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DOI: 10.3390/cancers14061419
Abstract: Simple Summary Anandamide (AEA) belongs to the group of endocannabinoids and possesses various regulatory properties in physiological as well as pathological processes occurring in the organism. In this research some basic biological tests were applied… read more here.
Keywords: metabolism; cell; glycosylation profile; melanoma ... See more keywords