Glycyrrhetinic Acid Accelerates the Clearance of Triptolide through P‐gp In Vitro
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5831
Abstract: Triptolide (TP) is an active ingredient isolated from Tripterygium wilfordii Hook. f. (TWHF), which is a traditional herbal medicine widely used for the treatment of rheumatoid arthritis and autoimmune disease in the clinic. However, its… read more here.
Keywords: glycyrrhetinic acid; clearance triptolide; acid accelerates; accelerates clearance ... See more keywords
Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201703306
Abstract: Mitochondria-mediated apoptosis (MMA) is a preferential option for cancer therapy due to the presence of cell-suicide factors in mitochondria, however, low permeability of mitochondria is a bottleneck for targeting drug delivery. In this paper, glycyrrhetinic… read more here.
Keywords: graphene oxide; glycyrrhetinic acid; functionalized graphene; delivery ... See more keywords
Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02344-2
Abstract: As pharmacophore hybridization has been used frequently in the discovery of new drugs, ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids have been synthesized and evaluated their antiproliferative activity by the MTT assay. The results displayed that, the hybrids… read more here.
Keywords: thymine hybrids; glycyrrhetinic acid; ursolic acid; acid ... See more keywords
Comparative study of selective in vitro and in silico BACE1 inhibitory potential of glycyrrhizin together with its metabolites, 18α- and 18β-glycyrrhetinic acid, isolated from Hizikia fusiformis
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-018-1018-2
Abstract: Hizikia fusiformis (Harvey) Okamura is a brown seaweed widely used in Korea and Japan, and it contains different therapeutically active constituents. In the present study, we investigated the activities of glycyrrhizin isolated from H. fusiformis,… read more here.
Keywords: hizikia fusiformis; metabolites glycyrrhetinic; glycyrrhetinic acid; study ... See more keywords
Protective effects of 18β-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108749
Abstract: PURPOSE Excessive proliferation, migration and anti-apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the basis for the development of pulmonary vascular remodeling, and it is the driving force for pulmonary arterial hypertension (PAH). 18β-glycyrrhetinic… read more here.
Keywords: glycyrrhetinic acid; arterial hypertension; pulmonary arterial; rho ... See more keywords
18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2018.04.012
Abstract: Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying… read more here.
Keywords: glycyrrhetinic acid; radiation induced; induced skin; skin damage ... See more keywords
Purification and characterization of a novel β-glucuronidase precisely converts glycyrrhizin to glycyrrhetinic acid 3-O-mono-β-D-glucuronide from plant endophytic Chaetomium globosum DX-THS3.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.047
Abstract: Glycyrrhetinic acid monoglucuronide (GAMG) is an innovative functional sweetener with higher sweetness and stronger pharmacological activity than glycyrrhizin (GL). A novel β-glucuronidase (cg-GUS) was firstly screened from plant endophytic fungus Chaetomium globosum DX-THS3. The cg-GUS… read more here.
Keywords: glycyrrhetinic acid; plant endophytic; glycyrrhizin; glucuronidase ... See more keywords
Glycyrrhetinic acid attenuates lipopolysaccharide‐induced fulminant hepatic failure in d‐galactosamine‐sensitized mice by up‐regulating expression of interleukin‐1 receptor‐associated kinase‐M
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.02.011
Abstract: ABSTRACT Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti‐inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30,… read more here.
Keywords: glycyrrhetinic acid; tnf agr; expression; receptor ... See more keywords
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05455
Abstract: 18β-Glycyrrhetinic acid (GA) is a triterpenoid possessing an anti-inflammatory activity in vivo, while the low bioavailability limits its application due to its intestinal accumulation. In order to investigate the metabolism of GA in intestinal microbes,… read more here.
Keywords: fungus aspergillus; intestinal fungus; glycyrrhetinic acid; anti inflammatory ... See more keywords
Liver-Targeted Co-delivery of Entecavir and Glycyrrhetinic Acid Based on Albumin Nanoparticle To Enhance the Accumulation of Entecavir.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00408
Abstract: Hepatitis B, one of the most common contagious viral hepatitis with high infection rate, is challenging to treat. Although the treatment for hepatitis B has been improved over the years, many therapeutic drugs still have… read more here.
Keywords: accumulation entecavir; delivery; glycyrrhetinic acid;
Enhanced Allicin Cytotoxicity on HEPG-2 Cells Using Glycyrrhetinic Acid Surface-Decorated Gelatin Nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01580
Abstract: The cytotoxic potential of allicin was evaluated on different cancer cell lines, particularly, hepatic (HepG-2), breast (MCF-7), lung (A-549), and prostatic (PC-3), where allicin scored an IC50 score of 19.26 μM on HepG-2. In order… read more here.
Keywords: hepg; glycyrrhetinic acid; gelatin nanoparticles; allicin ... See more keywords