Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5147-6
Abstract: BackgroundThe glymphatic system has recently been proposed to function as a brain-wide macroscopic system for the clearance of potentially harmful molecules, such as amyloid beta (e.g., Aβ), from the brain parenchyma. Previous literatures have established… read more here.
Keywords: chronic stress; glymphatic function; group; stress ... See more keywords
Neurosurgery and the glymphatic system
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-024-06161-4
Abstract: The discovery of the glymphatic system has fundamentally altered our comprehension of cerebrospinal fluid transport and the removal of waste from brain metabolism. In the past decade, since its initial characterization, research on the glymphatic… read more here.
Keywords: system; meningeal lymphatic; glymphatic system; neurosurgery glymphatic ... See more keywords
The glymphatic system for neurosurgeons: a scoping review
Sign Up to like & getrecommendations! Published in 2024 at "Neurosurgical Review"
DOI: 10.1007/s10143-024-02291-6
Abstract: The discovery of the glymphatic system has revolutionized our understanding of cerebrospinal fluid (CSF) circulation and interstitial waste clearance in the brain. This scoping review aims to synthesize the current literature on the glymphatic system’s… read more here.
Keywords: system; glymphatic system; neurosurgical conditions; glymphatic function ... See more keywords
Glymphatic MRI techniques in sleep and neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pulmonary Medicine"
DOI: 10.1097/mcp.0000000000000923
Abstract: Purpose of review The purpose of this review article is to summarize the current in-vivo imaging techniques for the evaluation of the glymphatic function and discuss the factors influencing the glymphatic function and research directions… read more here.
Keywords: mri; glymphatic mri; mri techniques; glymphatic function ... See more keywords
Assessing Glymphatic Function, Global Brain Activity, and Cognitive Performance in Adolescents Living With Perinatal HIV Exposure
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.70105
Abstract: The discovery of the glymphatic system has provided a theoretical framework for understanding neurofluid dynamics and waste clearance within the brain. Recent studies suggest that the function of the glymphatic system is also reflected in… read more here.
Keywords: perinatal hiv; brain; brain activity; function ... See more keywords
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-022-00291-4
Abstract: Background Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in the… read more here.
Keywords: lateral sclerosis; function early; function; amyotrophic lateral ... See more keywords
Reader Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000206874
Abstract: In this article, Siow et al.1,2 used diffusion tensor imaging along the perivascular space (DTI-ALPS) as a marker of glymphatic function in community-dwelling older adults. We raise 4 notes of caution in interpreting the findings… read more here.
Keywords: function; older adults; community dwelling; function community ... See more keywords
Association between body mass index and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-23-1032
Abstract: Background Obesity is considered a risk factor for the development of several neurodegenerative diseases, including Parkinson’s disease (PD). Recent studies have revealed that glymphatic function is compromised in PD patients. This study aims to investigate… read more here.
Keywords: diffusion tensor; glymphatic function; alps index; index ... See more keywords
Glymphatic Function as a Moderator in White Matter Injury and Cognitive Impairment: A Community-Dwelling Cohort Study
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a8846
Abstract: Graphical Abstract BACKGROUND AND PURPOSE: White matter injury (WMI) is associated with cognitive dysfunction in aging populations; however, a clinicoradiologic discrepancy often arises between WMI and cognition function in clinical practice. Emerging evidence suggests that… read more here.
Keywords: white matter; glymphatic function; matter; injury ... See more keywords
The Influence of Demographics and Vascular Risk Factors on Glymphatic Function Measured by Diffusion Along Perivascular Space
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.693787
Abstract: Assessing glymphatic function using in-vivo imaging method is of great value for understanding its contribution to major brain diseases. In the present study, we aim to validate the association between a variety of risk factors… read more here.
Keywords: index; glymphatic function; diffusion; alps index ... See more keywords
Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.788519
Abstract: Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) leads… read more here.
Keywords: pulsation; glymphatic function; model; cognitive impairment ... See more keywords