Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5147-6
Abstract: BackgroundThe glymphatic system has recently been proposed to function as a brain-wide macroscopic system for the clearance of potentially harmful molecules, such as amyloid beta (e.g., Aβ), from the brain parenchyma. Previous literatures have established… read more here.
Keywords: chronic stress; glymphatic function; group; stress ... See more keywords
Glymphatic MRI techniques in sleep and neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pulmonary Medicine"
DOI: 10.1097/mcp.0000000000000923
Abstract: Purpose of review The purpose of this review article is to summarize the current in-vivo imaging techniques for the evaluation of the glymphatic function and discuss the factors influencing the glymphatic function and research directions… read more here.
Keywords: mri; glymphatic mri; mri techniques; glymphatic function ... See more keywords
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-022-00291-4
Abstract: Background Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in the… read more here.
Keywords: lateral sclerosis; function early; function; amyotrophic lateral ... See more keywords
Reader Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000206874
Abstract: In this article, Siow et al.1,2 used diffusion tensor imaging along the perivascular space (DTI-ALPS) as a marker of glymphatic function in community-dwelling older adults. We raise 4 notes of caution in interpreting the findings… read more here.
Keywords: function; older adults; community dwelling; function community ... See more keywords
The Influence of Demographics and Vascular Risk Factors on Glymphatic Function Measured by Diffusion Along Perivascular Space
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.693787
Abstract: Assessing glymphatic function using in-vivo imaging method is of great value for understanding its contribution to major brain diseases. In the present study, we aim to validate the association between a variety of risk factors… read more here.
Keywords: index; glymphatic function; diffusion; alps index ... See more keywords
Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.788519
Abstract: Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) leads… read more here.
Keywords: pulsation; glymphatic function; model; cognitive impairment ... See more keywords