A pair of residue substitutions at the outer mouth of the channel pore act as inputs for a Boolean logic "OR" gate based on the glycine receptor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00522
Abstract: The glycine receptor (GlyR) is a ligand-activated chloride channel, whose mutations are the major cause of hereditary hyperekplexia. The hyperekplexia-causing R271Q mutation, which is located at the extracellular outer mouth of the channel pore, dramatically… read more here.
Keywords: mouth channel; gate; glycine receptor; glyr ... See more keywords
Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00158
Abstract: Glycine receptors (GlyRs) containing the α2 subunit regulate cortical interneuron migration. Disruption of the GlyR α2 subunit gene (Glra2) in mice leads to disrupted dorsal cortical progenitor homeostasis, leading to a depletion of projection neurons… read more here.
Keywords: r323l; autism; glyr subunit; glyr ... See more keywords
Impaired Glycine Receptor Trafficking in Neurological Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00291
Abstract: Ionotropic glycine receptors (GlyRs) enable fast synaptic neurotransmission in the adult spinal cord and brainstem. The inhibitory GlyR is a transmembrane glycine-gated chloride channel. The immature GlyR protein undergoes various processing steps, e.g., folding, assembly,… read more here.
Keywords: startle disease; life cycle; glyr; receptor trafficking ... See more keywords
Nociception in the Glycine Receptor Deficient Mutant Mouse Spastic
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.832490
Abstract: Glycine receptors (GlyRs) are the primary mediators of fast inhibitory transmission in the mammalian spinal cord, where they modulate sensory and motor signaling. Mutations in GlyR genes as well as some other genes underlie the… read more here.
Keywords: mouse spastic; deficient mutant; glycine; mice ... See more keywords
Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1089101
Abstract: Glycine receptor (GlyR) autoantibodies are associated with stiff-person syndrome and the life-threatening progressive encephalomyelitis with rigidity and myoclonus in children and adults. Patient histories show variability in symptoms and responses to therapeutic treatments. A better… read more here.
Keywords: non glycosylated; autoantibody; glycosylation; receptor ... See more keywords