P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.07.018
Abstract: Glycinergic inhibitory neurons of the spinal dorsal horn exert critical control over the conduction of nociceptive signals to higher brain areas. The neuronal glycine transporter 2 (GlyT2) is involved in the recycling of synaptic glycine… read more here.
Keywords: p2x; glycine transporter; expression; neuronal glycine ... See more keywords
Molecular and Electrophysiological Characterization of Dorsal Horn Neurons in a GlyT2-iCre-tdTomato Mouse Line
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pain Research"
DOI: 10.2147/jpr.s296940
Abstract: Purpose Spinal glycinergic neurons function as critical elements of a spinal gate for pain and itch. We have recently documented that spinal PKCγ+ neurons receive the feedforward inhibitory input driven by Aβ primary afferent. The… read more here.
Keywords: glyt2 tdtomato; glyt2; mice; glycinergic neurons ... See more keywords
Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201708
Abstract: Cholesterol binds to the GlyT2 SLC6 transporter, enhancing the effect of bioactive lipid analgesics, providing new therapeutic avenues to treat neuropathic pain and target SLC6 transporters. Membrane cholesterol binds to and modulates the function of… read more here.
Keywords: inhibition; membrane cholesterol; transport; glyt2 ... See more keywords
Modification of a Putative Third Sodium Site in the Glycine Transporter GlyT2 Influences the Chloride Dependence of Substrate Transport
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00347
Abstract: Neurotransmitter removal from glycine-mediated synapses relies on two sodium-driven high-affinity plasma membrane GlyTs that control neurotransmitter availability. Mostly glial GlyT1 is the main regulator of glycine synaptic levels, whereas neuronal GlyT2 promotes the recycling of… read more here.
Keywords: third sodium; transport; sodium; site ... See more keywords
Synergistic Control of Transmitter Turnover at Glycinergic Synapses by GlyT1, GlyT2, and ASC-1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052561
Abstract: In addition to being involved in protein biosynthesis and metabolism, the amino acid glycine is the most important inhibitory neurotransmitter in caudal regions of the brain. These functions require a tight regulation of glycine concentration… read more here.
Keywords: control transmitter; transmitter turnover; synergistic control; high affinity ... See more keywords